Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation

Shu Chen Hsieh, Nien Tsu Chen, Su Hao Lo

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

To understand the role of tumor suppressor PTEN in cartilage development, we have generated chondrocyte specific PTEN deletion mice using Col2a1Cre and PTENloxp/loxp mice. PTEN mutant mice are viable and fertile, nonetheless, develop kyphosis over time. Histological analyses show mutant vertebrae and intervertebral discs are larger and therefore the spines are longer than in control mice. In addition, the growth plates are thicker, invading trabecular bone areas are deeper, and marrow adipocyte populations are higher in PTEN mutant mice. Furthermore, the growth plates, not normally fused in mouse long bones, are fused in PTEN mutants. Intriguingly, PTEN mice develop lipomas and show abnormal accumulation of fat tissues along spines. Cell tracking assays have confirmed that lipomas and a portion of fat tissues were derived from Col2a1Cre PTENloxp/loxp cells. Further analyses have suggested that the phenotypes of PTEN mutant likely attribute to PTEN's negatively regulating role in PI3K/Akt pathway.

Original languageEnglish (US)
Pages (from-to)545-552
Number of pages8
JournalMolecular Carcinogenesis
Volume48
Issue number6
DOIs
StatePublished - Jun 2009

Keywords

  • Cartilage
  • Lipoma
  • PTEN
  • Spine

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology

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