Concurrent irradiation and intratumoral chemotherapy with cisplatin for treatment of a fibrosarcoma in a blue and gold macaw (Ara ararauna)

Nadine Lamberski, Alain P Theon

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

A myxoid fibrosarcoma in the wing of a blue and gold macaw (Ara ararauna) was treated with radiation therapy and intratumoral chemotherapy with cisplatin. The tumor was treated with a radiation dose of 40 Gy delivered during 22 days on an alternate-day schedule of 4 Gy/fraction and 3 chemotherapy treatments given once weekly at a dose of 0.3 mg of cisplatin per cm3 of tissue. Treatment was effective, and adverse effects were not noted clinically. Complete tumor remission was observed within 2 months after treatment completion, and the remission lasted 15 months until the macaw died of an unrelated cause. A cumulative effect of repeated intratumoral administrations on plasma concentrations of cisplatin was not observed during the course of treatment, although only trough levels were measured. Cisplatin-related systemic toxicities monitored by complete blood count and serum biochemical analysis were not found. Acute local reactions including edema and necrosis of the skin were self-limiting. Treatment complications included a decreased range of motion of the involved carpus. This may have resulted from radiation-induced fibrosis and bony fusion associated with bone remodeling. Results provide preliminary evidence that concurrent irradiation and intralesional chemotherapy may be an effective treatment for unresectable tumors in birds.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalJournal of Avian Medicine and Surgery
Volume16
Issue number3
StatePublished - Sep 2002

Keywords

  • Ara ararauna
  • Avian
  • Blue and gold macaw
  • Chemotherapy
  • Cisplatin
  • Fibrosarcoma
  • Neoplasm

ASJC Scopus subject areas

  • veterinary(all)

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