Abstract
A myxoid fibrosarcoma in the wing of a blue and gold macaw (Ara ararauna) was treated with radiation therapy and intratumoral chemotherapy with cisplatin. The tumor was treated with a radiation dose of 40 Gy delivered during 22 days on an alternate-day schedule of 4 Gy/fraction and 3 chemotherapy treatments given once weekly at a dose of 0.3 mg of cisplatin per cm3 of tissue. Treatment was effective, and adverse effects were not noted clinically. Complete tumor remission was observed within 2 months after treatment completion, and the remission lasted 15 months until the macaw died of an unrelated cause. A cumulative effect of repeated intratumoral administrations on plasma concentrations of cisplatin was not observed during the course of treatment, although only trough levels were measured. Cisplatin-related systemic toxicities monitored by complete blood count and serum biochemical analysis were not found. Acute local reactions including edema and necrosis of the skin were self-limiting. Treatment complications included a decreased range of motion of the involved carpus. This may have resulted from radiation-induced fibrosis and bony fusion associated with bone remodeling. Results provide preliminary evidence that concurrent irradiation and intralesional chemotherapy may be an effective treatment for unresectable tumors in birds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 234-238 |
| Number of pages | 5 |
| Journal | Journal of Avian Medicine and Surgery |
| Volume | 16 |
| Issue number | 3 |
| State | Published - Sep 2002 |
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Keywords
- Ara ararauna
- Avian
- Blue and gold macaw
- Chemotherapy
- Cisplatin
- Fibrosarcoma
- Neoplasm
ASJC Scopus subject areas
- veterinary(all)
Cite this
Concurrent irradiation and intratumoral chemotherapy with cisplatin for treatment of a fibrosarcoma in a blue and gold macaw (Ara ararauna). / Lamberski, Nadine; Theon, Alain P.
In: Journal of Avian Medicine and Surgery, Vol. 16, No. 3, 09.2002, p. 234-238.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Concurrent irradiation and intratumoral chemotherapy with cisplatin for treatment of a fibrosarcoma in a blue and gold macaw (Ara ararauna)
AU - Lamberski, Nadine
AU - Theon, Alain P
PY - 2002/9
Y1 - 2002/9
N2 - A myxoid fibrosarcoma in the wing of a blue and gold macaw (Ara ararauna) was treated with radiation therapy and intratumoral chemotherapy with cisplatin. The tumor was treated with a radiation dose of 40 Gy delivered during 22 days on an alternate-day schedule of 4 Gy/fraction and 3 chemotherapy treatments given once weekly at a dose of 0.3 mg of cisplatin per cm3 of tissue. Treatment was effective, and adverse effects were not noted clinically. Complete tumor remission was observed within 2 months after treatment completion, and the remission lasted 15 months until the macaw died of an unrelated cause. A cumulative effect of repeated intratumoral administrations on plasma concentrations of cisplatin was not observed during the course of treatment, although only trough levels were measured. Cisplatin-related systemic toxicities monitored by complete blood count and serum biochemical analysis were not found. Acute local reactions including edema and necrosis of the skin were self-limiting. Treatment complications included a decreased range of motion of the involved carpus. This may have resulted from radiation-induced fibrosis and bony fusion associated with bone remodeling. Results provide preliminary evidence that concurrent irradiation and intralesional chemotherapy may be an effective treatment for unresectable tumors in birds.
AB - A myxoid fibrosarcoma in the wing of a blue and gold macaw (Ara ararauna) was treated with radiation therapy and intratumoral chemotherapy with cisplatin. The tumor was treated with a radiation dose of 40 Gy delivered during 22 days on an alternate-day schedule of 4 Gy/fraction and 3 chemotherapy treatments given once weekly at a dose of 0.3 mg of cisplatin per cm3 of tissue. Treatment was effective, and adverse effects were not noted clinically. Complete tumor remission was observed within 2 months after treatment completion, and the remission lasted 15 months until the macaw died of an unrelated cause. A cumulative effect of repeated intratumoral administrations on plasma concentrations of cisplatin was not observed during the course of treatment, although only trough levels were measured. Cisplatin-related systemic toxicities monitored by complete blood count and serum biochemical analysis were not found. Acute local reactions including edema and necrosis of the skin were self-limiting. Treatment complications included a decreased range of motion of the involved carpus. This may have resulted from radiation-induced fibrosis and bony fusion associated with bone remodeling. Results provide preliminary evidence that concurrent irradiation and intralesional chemotherapy may be an effective treatment for unresectable tumors in birds.
KW - Ara ararauna
KW - Avian
KW - Blue and gold macaw
KW - Chemotherapy
KW - Cisplatin
KW - Fibrosarcoma
KW - Neoplasm
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UR - http://www.scopus.com/inward/citedby.url?scp=0036765412&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0036765412
VL - 16
SP - 234
EP - 238
JO - Journal of Avian Medicine and Surgery
JF - Journal of Avian Medicine and Surgery
SN - 1082-6742
IS - 3
ER -