Concurrent associations between expressive language ability and independence in adolescents and adults with fragile x syndrome

Leonard Abbeduto, Jessica Klusek, Julie Lounds Taylor, Nadia Abdelnur, Nicole Sparapani, Angela John Thurman

Research output: Contribution to journalArticlepeer-review


Background. Few individuals with fragile X syndrome (FXS) successfully meet adult normative expectations in education, employment, peer relations, and habitation, although there is within‐syndrome variability in this regard. The primary goal of this study was to determine whether expressive language skills contribute to the capacity for independent functioning in adulthood even after controlling for nonverbal cognitive ability. Methods. Participants were 18‐ to 23‐year‐olds with FXS. Expressive language was assessed using the psychometrically validated Expressive Language Sampling (ELS) conversation and narration procedures. The language produced was transcribed and analyzed to yield measures of expressive vocabulary, syntax, and intelligibility. Parents concurrently completed questionnaires on the independent functioning of the participants with FXS. Results. All three ELS measures were significantly corelated with multiple measures of independence. The magnitudes of the correlations were reduced when nonverbal IQ was controlled through partial correlation. Nonetheless, many of the partial correlations were medium to large and several were statistically significant. Conclusions. Expressive language skills appear to contribute uniquely to the capacity for independence, although longitudinal data are needed to evaluate the possibility of a bidirectional relationship between these domains. Thus, language intervention may be a prerequisite for preparing youth with FXS for an independent adult life.

Original languageEnglish (US)
Article number1179
JournalBrain Sciences
Issue number9
StatePublished - Sep 2021


  • Daily living skills
  • Expressive language
  • Fragile X syndrome
  • Independent functioning

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Concurrent associations between expressive language ability and independence in adolescents and adults with fragile x syndrome'. Together they form a unique fingerprint.

Cite this