Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches

Maryam Moshref, Bonnie Tangey, Chen Gilor, Klearchos K. Papas, Peter Williamson, Lindsey A Loomba-Albrecht, Paul Sheehy, Amir Kol

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Diabetes mellitus (DM) is a common spontaneous endocrine disorder in dogs, which is defined by persistent hyperglycemia and insulin deficiency. Like type 1 diabetes (T1D) in people, canine DM is a complex and multifactorial disease in which genomic and epigenomic factors interact with environmental cues to induce pancreatic β-cell loss and insulin deficiency, although the pathogenesis of canine DM is poorly defined and the role of autoimmunity is further controversial. Both diseases are incurable and require life-long exogenous insulin therapy to maintain glucose homeostasis. Human pancreatic islet physiology, size, and cellular composition is further mirrored by canine islets. Although pancreas, or isolated islets transplantation are the only clinically validated methods to achieve long-term normoglycemia and insulin–independence, their availability does not meet the clinical need, they target a small portion of patients and have significant potential adverse effects. Therefore, providing a new source for β-cell replacement is an unmet need. Naturally occurring DM in pet dogs, as a translational platform, is an untapped resource for various regenerative medicine applications that may offer some unique advantages given dogs' large size, longevity, heterogenic genetic background, similarity to human physiology and pathology and long-term clinical management. In this review, we outline different strategies for curative approaches, animal models used, and consider the value of canine DM as a translational animal/disease model for T1D in people. Stem Cells Translational Medicine 2019.

Original languageEnglish (US)
JournalStem cells translational medicine
DOIs
StatePublished - Jan 1 2019

Fingerprint

Regenerative Medicine
Canidae
Diabetes Mellitus
Dogs
Insulin
Type 1 Diabetes Mellitus
Animal Disease Models
Islets of Langerhans Transplantation
Translational Medical Research
Pets
Autoimmunity
Islets of Langerhans
Epigenomics
Hyperglycemia
Cues
Pancreas
Homeostasis
Stem Cells
Animal Models
Pathology

Keywords

  • Diabetes
  • Disease models
  • Dog
  • Regenerative medicine
  • Translational research

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

Concise Review : Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches. / Moshref, Maryam; Tangey, Bonnie; Gilor, Chen; Papas, Klearchos K.; Williamson, Peter; Loomba-Albrecht, Lindsey A; Sheehy, Paul; Kol, Amir.

In: Stem cells translational medicine, 01.01.2019.

Research output: Contribution to journalReview article

@article{b0f725914a12441f96909b2211d6e5ce,
title = "Concise Review: Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches",
abstract = "Diabetes mellitus (DM) is a common spontaneous endocrine disorder in dogs, which is defined by persistent hyperglycemia and insulin deficiency. Like type 1 diabetes (T1D) in people, canine DM is a complex and multifactorial disease in which genomic and epigenomic factors interact with environmental cues to induce pancreatic β-cell loss and insulin deficiency, although the pathogenesis of canine DM is poorly defined and the role of autoimmunity is further controversial. Both diseases are incurable and require life-long exogenous insulin therapy to maintain glucose homeostasis. Human pancreatic islet physiology, size, and cellular composition is further mirrored by canine islets. Although pancreas, or isolated islets transplantation are the only clinically validated methods to achieve long-term normoglycemia and insulin–independence, their availability does not meet the clinical need, they target a small portion of patients and have significant potential adverse effects. Therefore, providing a new source for β-cell replacement is an unmet need. Naturally occurring DM in pet dogs, as a translational platform, is an untapped resource for various regenerative medicine applications that may offer some unique advantages given dogs' large size, longevity, heterogenic genetic background, similarity to human physiology and pathology and long-term clinical management. In this review, we outline different strategies for curative approaches, animal models used, and consider the value of canine DM as a translational animal/disease model for T1D in people. Stem Cells Translational Medicine 2019.",
keywords = "Diabetes, Disease models, Dog, Regenerative medicine, Translational research",
author = "Maryam Moshref and Bonnie Tangey and Chen Gilor and Papas, {Klearchos K.} and Peter Williamson and Loomba-Albrecht, {Lindsey A} and Paul Sheehy and Amir Kol",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/sctm.18-0163",
language = "English (US)",
journal = "Stem cells translational medicine",
issn = "2157-6564",
publisher = "AlphaMed Press",

}

TY - JOUR

T1 - Concise Review

T2 - Canine Diabetes Mellitus as a Translational Model for Innovative Regenerative Medicine Approaches

AU - Moshref, Maryam

AU - Tangey, Bonnie

AU - Gilor, Chen

AU - Papas, Klearchos K.

AU - Williamson, Peter

AU - Loomba-Albrecht, Lindsey A

AU - Sheehy, Paul

AU - Kol, Amir

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Diabetes mellitus (DM) is a common spontaneous endocrine disorder in dogs, which is defined by persistent hyperglycemia and insulin deficiency. Like type 1 diabetes (T1D) in people, canine DM is a complex and multifactorial disease in which genomic and epigenomic factors interact with environmental cues to induce pancreatic β-cell loss and insulin deficiency, although the pathogenesis of canine DM is poorly defined and the role of autoimmunity is further controversial. Both diseases are incurable and require life-long exogenous insulin therapy to maintain glucose homeostasis. Human pancreatic islet physiology, size, and cellular composition is further mirrored by canine islets. Although pancreas, or isolated islets transplantation are the only clinically validated methods to achieve long-term normoglycemia and insulin–independence, their availability does not meet the clinical need, they target a small portion of patients and have significant potential adverse effects. Therefore, providing a new source for β-cell replacement is an unmet need. Naturally occurring DM in pet dogs, as a translational platform, is an untapped resource for various regenerative medicine applications that may offer some unique advantages given dogs' large size, longevity, heterogenic genetic background, similarity to human physiology and pathology and long-term clinical management. In this review, we outline different strategies for curative approaches, animal models used, and consider the value of canine DM as a translational animal/disease model for T1D in people. Stem Cells Translational Medicine 2019.

AB - Diabetes mellitus (DM) is a common spontaneous endocrine disorder in dogs, which is defined by persistent hyperglycemia and insulin deficiency. Like type 1 diabetes (T1D) in people, canine DM is a complex and multifactorial disease in which genomic and epigenomic factors interact with environmental cues to induce pancreatic β-cell loss and insulin deficiency, although the pathogenesis of canine DM is poorly defined and the role of autoimmunity is further controversial. Both diseases are incurable and require life-long exogenous insulin therapy to maintain glucose homeostasis. Human pancreatic islet physiology, size, and cellular composition is further mirrored by canine islets. Although pancreas, or isolated islets transplantation are the only clinically validated methods to achieve long-term normoglycemia and insulin–independence, their availability does not meet the clinical need, they target a small portion of patients and have significant potential adverse effects. Therefore, providing a new source for β-cell replacement is an unmet need. Naturally occurring DM in pet dogs, as a translational platform, is an untapped resource for various regenerative medicine applications that may offer some unique advantages given dogs' large size, longevity, heterogenic genetic background, similarity to human physiology and pathology and long-term clinical management. In this review, we outline different strategies for curative approaches, animal models used, and consider the value of canine DM as a translational animal/disease model for T1D in people. Stem Cells Translational Medicine 2019.

KW - Diabetes

KW - Disease models

KW - Dog

KW - Regenerative medicine

KW - Translational research

UR - http://www.scopus.com/inward/record.url?scp=85061066302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061066302&partnerID=8YFLogxK

U2 - 10.1002/sctm.18-0163

DO - 10.1002/sctm.18-0163

M3 - Review article

C2 - 30719867

AN - SCOPUS:85061066302

JO - Stem cells translational medicine

JF - Stem cells translational medicine

SN - 2157-6564

ER -