Concerted evolution of tRNA genes: Intergenic conversion among three unlinked serine tRNA genes in S. pombe

H. Amstutz, P. Munz, W. D. Heyer, U. Leupold, J. Kohli

Research output: Contribution to journalArticle

63 Scopus citations

Abstract

In many cases the multiple genes coding for one specific tRNA are dispersed throughout the genome. The members of such a gene family nevertheless maintain a common nucleotide sequence during evolution. A major mechanism contributing to this concerted evolution is intergenic conversion. Here we show that it occurs between three tRNA genes of related sequence residing on different chromosomes of Schizosaccharomyces pombe. Sequence analysis of converted genes indicates that blocks of a minimal length of 18-33 bp and of a maximal length of 190 bp can be transferred from one gene to the other. During melosis the frequency of these transfers lies in the order of 10-5 per progeny spore. Information transfer between any two members of the gene family occurs in both directions.

Original languageEnglish (US)
Pages (from-to)879-886
Number of pages8
JournalCell
Volume40
Issue number4
DOIs
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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