Computerized neurocognitive scanning: II. The profile of schizophrenia

Ruben C. Gur, John D Ragland, Paul J. Moberg, Warren B. Bilker, Christian Kohler, Steven J. Siegel, Raquel E. Gur

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

Cognitive Cleveland, OH,dysfunction in schizophrenia is well established with neuropsychological batteries, which have assessed multiple domains indicating diffuse deficits especially in processing related to frontotemporal systems. Two studies are reported examining the feasibility of the computerized neurocognitive scan to assess differential deficits in schizophrenia. In Study 1, we tested 53 patients and 71 controls with the traditional and computerized assessments counterbalanced in order. Both showed comparable generalized impairment in schizophrenia with differential deficits in executive functions and memory. The profile was replicated in Study 2 in a new sample of 68 patients and 37 controls, receiving only the computerized scan. The combined sample showed robust correlations between performance on both speed and accuracy measures of the neurocognitive scan and clinical variables, including premorbid adjustment, onset age, illness duration, quality of life, and severity of negative symptoms. These correlations were higher and more prevalent in women than men, who showed correlations predominantly for speed rather than accuracy. Neuroleptic exposure was associated with poorer performance only for speed of memory processing, and in men, this association was seen only for typical neuroleptics. We conclude that the computerized neurocognitive scan can be applied reliably in people with schizophrenia, yielding data that support its construct and criterion validity.

Original languageEnglish (US)
Pages (from-to)777-788
Number of pages12
JournalNeuropsychopharmacology
Volume25
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Schizophrenia
Antipsychotic Agents
Social Adjustment
Executive Function
Age of Onset
Quality of Life

Keywords

  • Computerized assessment
  • Neurocognition
  • Neuropsychological testing
  • Schizophrenia
  • Sex differences

ASJC Scopus subject areas

  • Pharmacology

Cite this

Gur, R. C., Ragland, J. D., Moberg, P. J., Bilker, W. B., Kohler, C., Siegel, S. J., & Gur, R. E. (2001). Computerized neurocognitive scanning: II. The profile of schizophrenia. Neuropsychopharmacology, 25(5), 777-788. https://doi.org/10.1016/S0893-133X(01)00279-2

Computerized neurocognitive scanning : II. The profile of schizophrenia. / Gur, Ruben C.; Ragland, John D; Moberg, Paul J.; Bilker, Warren B.; Kohler, Christian; Siegel, Steven J.; Gur, Raquel E.

In: Neuropsychopharmacology, Vol. 25, No. 5, 2001, p. 777-788.

Research output: Contribution to journalArticle

Gur, RC, Ragland, JD, Moberg, PJ, Bilker, WB, Kohler, C, Siegel, SJ & Gur, RE 2001, 'Computerized neurocognitive scanning: II. The profile of schizophrenia', Neuropsychopharmacology, vol. 25, no. 5, pp. 777-788. https://doi.org/10.1016/S0893-133X(01)00279-2
Gur, Ruben C. ; Ragland, John D ; Moberg, Paul J. ; Bilker, Warren B. ; Kohler, Christian ; Siegel, Steven J. ; Gur, Raquel E. / Computerized neurocognitive scanning : II. The profile of schizophrenia. In: Neuropsychopharmacology. 2001 ; Vol. 25, No. 5. pp. 777-788.
@article{eb7bdcb8001342148a8642828ef1d838,
title = "Computerized neurocognitive scanning: II. The profile of schizophrenia",
abstract = "Cognitive Cleveland, OH,dysfunction in schizophrenia is well established with neuropsychological batteries, which have assessed multiple domains indicating diffuse deficits especially in processing related to frontotemporal systems. Two studies are reported examining the feasibility of the computerized neurocognitive scan to assess differential deficits in schizophrenia. In Study 1, we tested 53 patients and 71 controls with the traditional and computerized assessments counterbalanced in order. Both showed comparable generalized impairment in schizophrenia with differential deficits in executive functions and memory. The profile was replicated in Study 2 in a new sample of 68 patients and 37 controls, receiving only the computerized scan. The combined sample showed robust correlations between performance on both speed and accuracy measures of the neurocognitive scan and clinical variables, including premorbid adjustment, onset age, illness duration, quality of life, and severity of negative symptoms. These correlations were higher and more prevalent in women than men, who showed correlations predominantly for speed rather than accuracy. Neuroleptic exposure was associated with poorer performance only for speed of memory processing, and in men, this association was seen only for typical neuroleptics. We conclude that the computerized neurocognitive scan can be applied reliably in people with schizophrenia, yielding data that support its construct and criterion validity.",
keywords = "Computerized assessment, Neurocognition, Neuropsychological testing, Schizophrenia, Sex differences",
author = "Gur, {Ruben C.} and Ragland, {John D} and Moberg, {Paul J.} and Bilker, {Warren B.} and Christian Kohler and Siegel, {Steven J.} and Gur, {Raquel E.}",
year = "2001",
doi = "10.1016/S0893-133X(01)00279-2",
language = "English (US)",
volume = "25",
pages = "777--788",
journal = "Neuropsychopharmacology",
issn = "0893-133X",
publisher = "Nature Publishing Group",
number = "5",

}

TY - JOUR

T1 - Computerized neurocognitive scanning

T2 - II. The profile of schizophrenia

AU - Gur, Ruben C.

AU - Ragland, John D

AU - Moberg, Paul J.

AU - Bilker, Warren B.

AU - Kohler, Christian

AU - Siegel, Steven J.

AU - Gur, Raquel E.

PY - 2001

Y1 - 2001

N2 - Cognitive Cleveland, OH,dysfunction in schizophrenia is well established with neuropsychological batteries, which have assessed multiple domains indicating diffuse deficits especially in processing related to frontotemporal systems. Two studies are reported examining the feasibility of the computerized neurocognitive scan to assess differential deficits in schizophrenia. In Study 1, we tested 53 patients and 71 controls with the traditional and computerized assessments counterbalanced in order. Both showed comparable generalized impairment in schizophrenia with differential deficits in executive functions and memory. The profile was replicated in Study 2 in a new sample of 68 patients and 37 controls, receiving only the computerized scan. The combined sample showed robust correlations between performance on both speed and accuracy measures of the neurocognitive scan and clinical variables, including premorbid adjustment, onset age, illness duration, quality of life, and severity of negative symptoms. These correlations were higher and more prevalent in women than men, who showed correlations predominantly for speed rather than accuracy. Neuroleptic exposure was associated with poorer performance only for speed of memory processing, and in men, this association was seen only for typical neuroleptics. We conclude that the computerized neurocognitive scan can be applied reliably in people with schizophrenia, yielding data that support its construct and criterion validity.

AB - Cognitive Cleveland, OH,dysfunction in schizophrenia is well established with neuropsychological batteries, which have assessed multiple domains indicating diffuse deficits especially in processing related to frontotemporal systems. Two studies are reported examining the feasibility of the computerized neurocognitive scan to assess differential deficits in schizophrenia. In Study 1, we tested 53 patients and 71 controls with the traditional and computerized assessments counterbalanced in order. Both showed comparable generalized impairment in schizophrenia with differential deficits in executive functions and memory. The profile was replicated in Study 2 in a new sample of 68 patients and 37 controls, receiving only the computerized scan. The combined sample showed robust correlations between performance on both speed and accuracy measures of the neurocognitive scan and clinical variables, including premorbid adjustment, onset age, illness duration, quality of life, and severity of negative symptoms. These correlations were higher and more prevalent in women than men, who showed correlations predominantly for speed rather than accuracy. Neuroleptic exposure was associated with poorer performance only for speed of memory processing, and in men, this association was seen only for typical neuroleptics. We conclude that the computerized neurocognitive scan can be applied reliably in people with schizophrenia, yielding data that support its construct and criterion validity.

KW - Computerized assessment

KW - Neurocognition

KW - Neuropsychological testing

KW - Schizophrenia

KW - Sex differences

UR - http://www.scopus.com/inward/record.url?scp=0034773263&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034773263&partnerID=8YFLogxK

U2 - 10.1016/S0893-133X(01)00279-2

DO - 10.1016/S0893-133X(01)00279-2

M3 - Article

C2 - 11682261

AN - SCOPUS:0034773263

VL - 25

SP - 777

EP - 788

JO - Neuropsychopharmacology

JF - Neuropsychopharmacology

SN - 0893-133X

IS - 5

ER -