Computer simulation of altered sodium channel gating in rabbit and human ventricular myocytes

Eleonora Grandi; Jose L. Puglisi; Stefano Severi; Donald M Bers

Computer simulation of altered sodium channel gating in rabbit and human ventricular myocytes

Eleonora Grandi, Jose L. Puglisi, Stefano Severi, Donald M Bers

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Mathematical models were used to explore sodium (Na) current alterations. Markovian representations were chosen to describe the Na current behavior under pathological conditions, such as genetic defects (Long QT and Brugada syndromes) or acquired diseases (heart failure). These Na current formulations were subsequently introduced in an integrated model of the ventricular myocyte to investigate their effects on the ventricular action potential. This "in silico" approach is a powerful tool, providing new insights into arrhythmia susceptibility due to inherited and/or acquired Na channelopathies.

Original language	English (US)
Title of host publication	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages	120-128
Number of pages	9
Volume	4466 LNCS
State	Published - 2007
Externally published	Yes
Event	4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007 - Salt Lake City, UT, United States Duration: Jun 7 2007 → Jun 9 2007

Other

Other	4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007
Country	United States
City	Salt Lake City, UT
Period	6/7/07 → 6/9/07

Keywords

Action potential
Arrhythmias
Na channelopathies

ASJC Scopus subject areas

Computer Science(all)
Biochemistry, Genetics and Molecular Biology(all)
Theoretical Computer Science

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Cite this

Computer simulation of altered sodium channel gating in rabbit and human ventricular myocytes. / Grandi, Eleonora; Puglisi, Jose L.; Severi, Stefano; Bers, Donald M.

Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). Vol. 4466 LNCS 2007. p. 120-128.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Grandi, E, Puglisi, JL, Severi, S & Bers, DM 2007, Computer simulation of altered sodium channel gating in rabbit and human ventricular myocytes. in Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). vol. 4466 LNCS, pp. 120-128, 4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007, Salt Lake City, UT, United States, 6/7/07.

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