Computer simulation of altered sodium channel gating in rabbit and human ventricular myocytes

Eleonora Grandi, Jose L. Puglisi, Stefano Severi, Donald M Bers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mathematical models were used to explore sodium (Na) current alterations. Markovian representations were chosen to describe the Na current behavior under pathological conditions, such as genetic defects (Long QT and Brugada syndromes) or acquired diseases (heart failure). These Na current formulations were subsequently introduced in an integrated model of the ventricular myocyte to investigate their effects on the ventricular action potential. This "in silico" approach is a powerful tool, providing new insights into arrhythmia susceptibility due to inherited and/or acquired Na channelopathies.

Original languageEnglish (US)
Title of host publicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages120-128
Number of pages9
Volume4466 LNCS
StatePublished - 2007
Externally publishedYes
Event4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007 - Salt Lake City, UT, United States
Duration: Jun 7 2007Jun 9 2007

Other

Other4th International Conference on Functional Imaging and Modeling of the Heart, FIMH 2007
CountryUnited States
CitySalt Lake City, UT
Period6/7/076/9/07

Keywords

  • Action potential
  • Arrhythmias
  • Na channelopathies

ASJC Scopus subject areas

  • Computer Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Theoretical Computer Science

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  • Cite this

    Grandi, E., Puglisi, J. L., Severi, S., & Bers, D. M. (2007). Computer simulation of altered sodium channel gating in rabbit and human ventricular myocytes. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4466 LNCS, pp. 120-128)