Computed tomographic pneumocolonography in normal dogs

Michele A Steffey, Leticia Daniel, Sandra L. Taylor, Rachel X. Chen, Allison Zwingenberger

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives of this prospective study were to describe effects of varying technical components that may contribute to an optimal protocol for computed tomographic pneumocolonography (CTP) in dogs, and to develop a standardized methodology for CTP as a future potential diagnostic tool in canine clinical patients with large bowel disease. Eight purpose-bred intact male hound cross-research dogs were enrolled and randomized to groups based on variables of pressure/body position (n = 4) and insufflation time (n = 4). For each segment of large bowel (rectum, colorectal junction, descending colon, transverse colon, ascending colon), the adequacy of bowel preparation, % of bowel lumen filled with fecal material, and bowel tortuosity or folding were assessed. Measurements of bowel wall thickness (cm), cross-sectional bowel lumen diameter (cm), and cross-sectional bowel luminal area (cm<sup>2</sup>) were obtained at standardized locations within the large bowel. False discovery rates (FDR) were calculated to adjust for multiple testing. Values of FDR < 0.05 were considered significant. Differences in mean cross-sectional area and diameter and bowel wall thickness under increasing pressure were not significant after adjusting for multiple testing; some had raw p values <0.05. Ascending colon diameter and ascending colon area significantly increased with insufflation time (FDR < 0.05). No other response variables showed a significant change with insufflation time. The optimal insufflation pressure for maintaining pneumocolon in this study was determined to be 20 mmHg. CTP is a feasible technique to provide consistent distension for imaging of the large bowel and further study on application of CTP in clinical patients is warranted.

Original languageEnglish (US)
Pages (from-to)278-285
Number of pages8
JournalVeterinary Radiology and Ultrasound
Volume56
Issue number3
DOIs
StatePublished - May 1 2015

Fingerprint

Insufflation
Ascending Colon
colon
Dogs
dogs
Pressure
Descending Colon
Transverse Colon
hounds
Rectum
Canidae
rectum
prospective studies
Prospective Studies
testing
image analysis
breeds
Research
methodology

Keywords

  • Computed tomography
  • Dog
  • Large bowel
  • Pneumocolonography

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Computed tomographic pneumocolonography in normal dogs. / Steffey, Michele A; Daniel, Leticia; Taylor, Sandra L.; Chen, Rachel X.; Zwingenberger, Allison.

In: Veterinary Radiology and Ultrasound, Vol. 56, No. 3, 01.05.2015, p. 278-285.

Research output: Contribution to journalArticle

Steffey, Michele A ; Daniel, Leticia ; Taylor, Sandra L. ; Chen, Rachel X. ; Zwingenberger, Allison. / Computed tomographic pneumocolonography in normal dogs. In: Veterinary Radiology and Ultrasound. 2015 ; Vol. 56, No. 3. pp. 278-285.
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