Computational approaches to understand cardiac electrophysiology and arrhythmias

Byron N. Roberts, Pei Chi Yang, Steven B. Behrens, Jonathan D. Moreno, Colleen E Clancy

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Cardiac rhythms arise from electrical activity generated by precisely timed opening and closing of ion channels in individual cardiac myocytes. These impulses spread throughout the cardiac muscle to manifest as electrical waves in the whole heart. Regularity of electrical waves is critically important since they signal the heart muscle to contract, driving the primary function of the heart to act as a pump and deliver blood to the brain and vital organs. When electrical activity goes awry during a cardiac arrhythmia, the pump does not function, the brain does not receive oxygenated blood, and death ensues. For more than 50 years, mathematically based models of cardiac electrical activity have been used to improve understanding of basic mechanisms of normal and abnormal cardiac electrical function. Computer-based modeling approaches to understand cardiac activity are uniquely helpful because they allow for distillation of complex emergent behaviors into the key contributing components underlying them. Here we review the latest advances and novel concepts in the field as they relate to understanding the complex interplay between electrical, mechanical, structural, and genetic mechanisms during arrhythmia development at the level of ion channels, cells, and tissues. We also discuss the latest computational approaches to guiding arrhythmia therapy.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume303
Issue number7
DOIs
StatePublished - Oct 1 2012

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Cardiac Electrophysiology
Cardiac Arrhythmias
Ion Channels
Myocardium
Distillation
Brain
Cardiac Myocytes
Therapeutics

Keywords

  • Arrhythmia
  • Cardiac electrophysiology
  • Ion channels
  • Therapy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Computational approaches to understand cardiac electrophysiology and arrhythmias. / Roberts, Byron N.; Yang, Pei Chi; Behrens, Steven B.; Moreno, Jonathan D.; Clancy, Colleen E.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 303, No. 7, 01.10.2012.

Research output: Contribution to journalArticle

Roberts, Byron N. ; Yang, Pei Chi ; Behrens, Steven B. ; Moreno, Jonathan D. ; Clancy, Colleen E. / Computational approaches to understand cardiac electrophysiology and arrhythmias. In: American Journal of Physiology - Heart and Circulatory Physiology. 2012 ; Vol. 303, No. 7.
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