Abstract
Optical techniques including fluorescence lifetime spectroscopy have demonstrated potential as a tool for study and diagnosis of arterial vessel pathologies. However, their application in the intravascular diagnostic procedures has been hampered by the presence of blood hemoglobin that affects the light delivery to and the collection from the vessel wall. We report a computational fluid dynamics model that allows for the optimization of blood flushing parameters in a manner that minimizes the amount of saline needed to clear the optical field of view and reduces any adverse effects caused by the external saline jet. A 3D turbulence (k - ω) model was employed for Eulerian-Eulerian two-phase flow to simulate the flow inside and around a side-viewing fiber-optic catheter. Current analysis demonstrates the effects of various parameters including infusion and blood flow rates, vessel diameters, and pulsatile nature of blood flow on the flow structure around the catheter tip. The results from this study can be utilized in determining the optimal flushing rate for given vessel diameter, blood flow rate, and maximum wall shear stress that the vessel wall can sustain and subsequently in optimizing the design parameters of optical-based intravascular catheters.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1278-1293 |
| Number of pages | 16 |
| Journal | International Journal for Numerical Methods in Biomedical Engineering |
| Volume | 30 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2014 |
Fingerprint
Keywords
- Eulerian-Eulerian two-phase flow
- k - ω turbulence model
- Mixture model
- Multiphase flow
ASJC Scopus subject areas
- Biomedical Engineering
- Molecular Biology
- Computational Theory and Mathematics
- Software
- Applied Mathematics
- Modeling and Simulation
Cite this
Computational analysis of the effectiveness of blood flushing with saline injection from an intravascular diagnostic catheter. / Ghata, Narugopal; Aldredge, Ralph C.; Bec, Julien; Marcu, Laura.
In: International Journal for Numerical Methods in Biomedical Engineering, Vol. 30, No. 11, 01.11.2014, p. 1278-1293.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Computational analysis of the effectiveness of blood flushing with saline injection from an intravascular diagnostic catheter
AU - Ghata, Narugopal
AU - Aldredge, Ralph C.
AU - Bec, Julien
AU - Marcu, Laura
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Optical techniques including fluorescence lifetime spectroscopy have demonstrated potential as a tool for study and diagnosis of arterial vessel pathologies. However, their application in the intravascular diagnostic procedures has been hampered by the presence of blood hemoglobin that affects the light delivery to and the collection from the vessel wall. We report a computational fluid dynamics model that allows for the optimization of blood flushing parameters in a manner that minimizes the amount of saline needed to clear the optical field of view and reduces any adverse effects caused by the external saline jet. A 3D turbulence (k - ω) model was employed for Eulerian-Eulerian two-phase flow to simulate the flow inside and around a side-viewing fiber-optic catheter. Current analysis demonstrates the effects of various parameters including infusion and blood flow rates, vessel diameters, and pulsatile nature of blood flow on the flow structure around the catheter tip. The results from this study can be utilized in determining the optimal flushing rate for given vessel diameter, blood flow rate, and maximum wall shear stress that the vessel wall can sustain and subsequently in optimizing the design parameters of optical-based intravascular catheters.
AB - Optical techniques including fluorescence lifetime spectroscopy have demonstrated potential as a tool for study and diagnosis of arterial vessel pathologies. However, their application in the intravascular diagnostic procedures has been hampered by the presence of blood hemoglobin that affects the light delivery to and the collection from the vessel wall. We report a computational fluid dynamics model that allows for the optimization of blood flushing parameters in a manner that minimizes the amount of saline needed to clear the optical field of view and reduces any adverse effects caused by the external saline jet. A 3D turbulence (k - ω) model was employed for Eulerian-Eulerian two-phase flow to simulate the flow inside and around a side-viewing fiber-optic catheter. Current analysis demonstrates the effects of various parameters including infusion and blood flow rates, vessel diameters, and pulsatile nature of blood flow on the flow structure around the catheter tip. The results from this study can be utilized in determining the optimal flushing rate for given vessel diameter, blood flow rate, and maximum wall shear stress that the vessel wall can sustain and subsequently in optimizing the design parameters of optical-based intravascular catheters.
KW - Eulerian-Eulerian two-phase flow
KW - k - ω turbulence model
KW - Mixture model
KW - Multiphase flow
UR - http://www.scopus.com/inward/record.url?scp=84911383410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84911383410&partnerID=8YFLogxK
U2 - 10.1002/cnm.2657
DO - 10.1002/cnm.2657
M3 - Article
C2 - 24953876
AN - SCOPUS:84911383410
VL - 30
SP - 1278
EP - 1293
JO - International Journal for Numerical Methods in Biomedical Engineering
JF - International Journal for Numerical Methods in Biomedical Engineering
SN - 2040-7939
IS - 11
ER -