Abstract
The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 18-21 |
| Number of pages | 4 |
| Journal | Veterinary Journal |
| Volume | 228 |
| DOIs | |
| State | Published - Oct 1 2017 |
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Keywords
- Drug resistance
- Immune response
- Inflammation
- Lymphoma
- Microenvironment
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma. / Suenaga, Miyu; Tomiyasu, Hirotaka; Watanabe, Manabu; Ogawa, Kotogo; Motegi, Tomoki; Goto-Koshino, Yuko; Ohno, Koichi; Sugano, Sumio; Skorupski, Katherine A; Tsujimoto, Hajime.
In: Veterinary Journal, Vol. 228, 01.10.2017, p. 18-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma
AU - Suenaga, Miyu
AU - Tomiyasu, Hirotaka
AU - Watanabe, Manabu
AU - Ogawa, Kotogo
AU - Motegi, Tomoki
AU - Goto-Koshino, Yuko
AU - Ohno, Koichi
AU - Sugano, Sumio
AU - Skorupski, Katherine A
AU - Tsujimoto, Hajime
PY - 2017/10/1
Y1 - 2017/10/1
N2 - The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.
AB - The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.
KW - Drug resistance
KW - Immune response
KW - Inflammation
KW - Lymphoma
KW - Microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85033489870&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85033489870&partnerID=8YFLogxK
U2 - 10.1016/j.tvjl.2017.10.002
DO - 10.1016/j.tvjl.2017.10.002
M3 - Article
C2 - 29153103
AN - SCOPUS:85033489870
VL - 228
SP - 18
EP - 21
JO - Veterinary Journal
JF - Veterinary Journal
SN - 1090-0233
ER -