Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma

Miyu Suenaga; Hirotaka Tomiyasu; Manabu Watanabe; Kotogo Ogawa; Tomoki Motegi; Yuko Goto-Koshino; Koichi Ohno; Sumio Sugano; Katherine A Skorupski; Hajime Tsujimoto

doi:10.1016/j.tvjl.2017.10.002

Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma

Miyu Suenaga, Hirotaka Tomiyasu, Manabu Watanabe, Kotogo Ogawa, Tomoki Motegi, Yuko Goto-Koshino, Koichi Ohno, Sumio Sugano, Katherine A Skorupski, Hajime Tsujimoto

Surgical and Radiological Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.

Original language	English (US)
Pages (from-to)	18-21
Number of pages	4
Journal	Veterinary Journal
Volume	228
DOIs	https://doi.org/10.1016/j.tvjl.2017.10.002
State	Published - Oct 1 2017

Keywords

Drug resistance
Immune response
Inflammation
Lymphoma
Microenvironment

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

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10.1016/j.tvjl.2017.10.002

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Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma. / Suenaga, Miyu; Tomiyasu, Hirotaka; Watanabe, Manabu; Ogawa, Kotogo; Motegi, Tomoki; Goto-Koshino, Yuko; Ohno, Koichi; Sugano, Sumio; Skorupski, Katherine A; Tsujimoto, Hajime.

In: Veterinary Journal, Vol. 228, 01.10.2017, p. 18-21.

Research output: Contribution to journal › Article › peer-review

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title = "Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma",

abstract = "The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.",

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AU - Motegi, Tomoki

AU - Goto-Koshino, Yuko

AU - Ohno, Koichi

AU - Sugano, Sumio

AU - Skorupski, Katherine A

AU - Tsujimoto, Hajime

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AB - The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.

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Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma

Abstract

Keywords

ASJC Scopus subject areas

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