Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma

Miyu Suenaga; Hirotaka Tomiyasu; Manabu Watanabe; Kotogo Ogawa; Tomoki Motegi; Yuko Goto-Koshino; Koichi Ohno; Sumio Sugano; Katherine A Skorupski; Hajime Tsujimoto

doi:10.1016/j.tvjl.2017.10.002

Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma

Miyu Suenaga, Hirotaka Tomiyasu, Manabu Watanabe, Kotogo Ogawa, Tomoki Motegi, Yuko Goto-Koshino, Koichi Ohno, Sumio Sugano, Katherine A Skorupski, Hajime Tsujimoto

Surgical and Radiological Sciences

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.

Original language	English (US)
Pages (from-to)	18-21
Number of pages	4
Journal	Veterinary Journal
Volume	228
DOIs	https://doi.org/10.1016/j.tvjl.2017.10.002
State	Published - Oct 1 2017

Keywords

Drug resistance
Immune response
Inflammation
Lymphoma
Microenvironment

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

Access to Document

10.1016/j.tvjl.2017.10.002

Fingerprint Dive into the research topics of 'Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma'. Together they form a unique fingerprint.

Cite this

Suenaga, M., Tomiyasu, H., Watanabe, M., Ogawa, K., Motegi, T., Goto-Koshino, Y., Ohno, K., Sugano, S., Skorupski, K. A., & Tsujimoto, H. (2017). Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma. Veterinary Journal, 228, 18-21. https://doi.org/10.1016/j.tvjl.2017.10.002

Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma. / Suenaga, Miyu; Tomiyasu, Hirotaka; Watanabe, Manabu; Ogawa, Kotogo; Motegi, Tomoki; Goto-Koshino, Yuko; Ohno, Koichi; Sugano, Sumio; Skorupski, Katherine A; Tsujimoto, Hajime.

In: Veterinary Journal, Vol. 228, 01.10.2017, p. 18-21.

Research output: Contribution to journal › Article

@article{19a39d428c1a42cb9021c94dddaa97d5,

title = "Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma",

abstract = "The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.",

keywords = "Drug resistance, Immune response, Inflammation, Lymphoma, Microenvironment",

author = "Miyu Suenaga and Hirotaka Tomiyasu and Manabu Watanabe and Kotogo Ogawa and Tomoki Motegi and Yuko Goto-Koshino and Koichi Ohno and Sumio Sugano and Skorupski, {Katherine A} and Hajime Tsujimoto",

year = "2017",

month = oct,

day = "1",

doi = "10.1016/j.tvjl.2017.10.002",

language = "English (US)",

volume = "228",

pages = "18--21",

journal = "Veterinary Journal",

issn = "1090-0233",

publisher = "Bailliere Tindall Ltd",

}

TY - JOUR

T1 - Comprehensive analysis of gene expression profiles reveals novel candidates of chemotherapy resistant factors in canine lymphoma

AU - Suenaga, Miyu

AU - Tomiyasu, Hirotaka

AU - Watanabe, Manabu

AU - Ogawa, Kotogo

AU - Motegi, Tomoki

AU - Goto-Koshino, Yuko

AU - Ohno, Koichi

AU - Sugano, Sumio

AU - Skorupski, Katherine A

AU - Tsujimoto, Hajime

PY - 2017/10/1

Y1 - 2017/10/1

N2 - The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.

AB - The molecular mechanisms of acquisition of chemotherapy resistance in canine lymphoma have not been elucidated. The aim of the present study was to identify novel molecular mechanisms of chemotherapy resistance by a comprehensive analysis of changes in gene expression profiles (GEPs). Tumor samples were obtained from 10 dogs with lymphoma at chemotherapy sensitive and chemotherapy resistant phases. During chemotherapy resistance, the expression of genes associated with immune responses and inflammatory reactions was decreased compared to chemotherapy sensitive phases. In addition, 11 genes, with significant changes in expression (P < 0.05), were extracted from seven dogs with chemotherapy resistant lymphoma. Further studies are needed to investigate the associations of these changes in GEPs with the acquisition of chemotherapy resistance in canine lymphoma.

KW - Drug resistance

KW - Immune response

KW - Inflammation

KW - Lymphoma

KW - Microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85033489870&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033489870&partnerID=8YFLogxK

U2 - 10.1016/j.tvjl.2017.10.002

DO - 10.1016/j.tvjl.2017.10.002

M3 - Article

C2 - 29153103

AN - SCOPUS:85033489870

VL - 228

SP - 18

EP - 21

JO - Veterinary Journal

JF - Veterinary Journal

SN - 1090-0233

ER -