Complications related to inadequate delivered dose: Recognition and management in acute and chronic dialysis

Jane Y Yeun, Thomas A. Depner

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Despite many improvements over the past three decades, hemodialysis fails to completely restore health in patients who have lost native kidney function, so debate continues about how much dialysis is enough. It is clear that uremic symptoms such as nausea, vomiting, pruritus, mental lethargy, and anorexia can appear in patients who are inadequately dialyzed and are certain to appear if dialysis is omitted. However, even in patients who have none of these overt symptoms, insufficient dialysis has been associated with an increase in the number and duration of hospitalizations and with a shortened life expectancy (1-4). Because these serious complications are potentially preventable, clinicians providing dialysis for patients with end-stage renal disease (ESRD) must have a practical understanding of dialysis adequacy, how to measure it, and the basis for currently acceptable minimum standards. This requires a working familiarity with the theoretical constructs of solute and membrane dynamics, the strategies to improve dialysis efficiency, and the pitfalls inherent in prescribing and supervising dialysis.

Original languageEnglish (US)
Title of host publicationComplications of Dialysis
PublisherCRC Press
Number of pages27
ISBN (Electronic)9780824745295
ISBN (Print)9780824788711
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Medicine(all)


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