Complications in Paget disease at MR imaging

Robert D Boutin, Damon J. Spitz, Joel S. Newman, Leon Lenchik, Lynne S. Steinbach

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

PURPOSE: To determine the MR imaging findings in patients with complications of Paget disease of bone. MATERIALS AND METHODS: Of 45 patients with Paget disease who underwent MR imaging, 33 (26 men, seven women; age range, 64-91 years) with known complications of the disease were examined. Imaging in this subgroup included radiography (n = 26), computed tomography (n = 12), bone scintigraphy (n = 15), and magnetic resonance (MR) imaging (n = 33). Patients were examined specifically for musculoskeletal and neurologic complications of Paget disease, including fracture, basilar impression, spinal stenosis, bone tumor, and osteoarthrosis. RESULTS: The 56 complications documented in the 33 patients were fracture (n = 17), neurologic entrapment (n = 19), neoplasm (n = 9), and arthropathy (n = 11). MR imaging was beneficial in the diagnostic evaluation of basilar impression (n = 7), spinal stenosis (n = 12), and the tumor stage (n = 9). It also helped to successfully evaluate pagetic bone narrowing of the coracoacromial arch, which was associated with impingement syndrome and rotator cuff rupture (n = 2). The signal intensities in pagetic bone were most commonly similar to those in fat; this finding had a 100% negative predictive value in excluding neoplasm. CONCLUSION: Although Paget disease is diagnosed economically with conventional radiography, MR imaging is well suited for demonstrating the presence and extent of several characteristic disease complications, including basilar impression, spinal stenosis, and secondary neoplasm.

Original languageEnglish (US)
Pages (from-to)641-651
Number of pages11
JournalRadiology
Volume209
Issue number3
StatePublished - Dec 1998

Keywords

  • Bones, CT
  • Bones, MR
  • Bones, radionuclide studies
  • Osteitis deformans

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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    Boutin, R. D., Spitz, D. J., Newman, J. S., Lenchik, L., & Steinbach, L. S. (1998). Complications in Paget disease at MR imaging. Radiology, 209(3), 641-651.