Complex genome evolution in Anopheles coluzzii associated with increased insecticide usage in Mali

Bradley Main, Yoosook Lee, Travis C. Collier, Laura C. Norris, Katherine Brisco, Abdrahamane Fofana, Anthony J. Cornel, Gregory C Lanzaro

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In certain cases, a species may have access to important genetic variation present in a related species via adaptive introgression. These novel alleles may interact with their new genetic background, resulting in unexpected phenotypes. In this study, we describe a selective sweep on standing variation on the X chromosome in the mosquito Anopheles coluzzii, a principal malaria vector in West Africa. This event may have been influenced by the recent adaptive introgression of the insecticide resistance gene known as kdr from the sister species Anopheles gambiae. Individuals carrying both kdr and a nearly fixed X-linked haplotype, encompassing at least four genes including the P450 gene CYP9K1 and the cuticular protein CPR125, have rapidly increased in relative frequency. In parallel, a reproductively isolated insecticide-susceptible A. gambiae population (Bamako form) has been driven to local extinction, likely due to strong selection from increased insecticide-treated bed net usage.

Original languageEnglish (US)
Pages (from-to)5145-5157
Number of pages13
JournalMolecular Ecology
Volume24
Issue number20
DOIs
StatePublished - Oct 1 2015

Fingerprint

Mali
Anopheles
Insecticides
insecticide
Anopheles gambiae
insecticides
genome
introgression
Genome
gene
Insecticide-Treated Bednets
bed nets
Insecticide Resistance
Genes
Western Africa
genes
local extinction
insecticide resistance
malaria
X Chromosome

Keywords

  • adaptive introgression
  • Anopheles
  • epistasis
  • hybridization
  • insecticide resistance
  • kdr
  • malaria vector
  • P450

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics

Cite this

Complex genome evolution in Anopheles coluzzii associated with increased insecticide usage in Mali. / Main, Bradley; Lee, Yoosook; Collier, Travis C.; Norris, Laura C.; Brisco, Katherine; Fofana, Abdrahamane; Cornel, Anthony J.; Lanzaro, Gregory C.

In: Molecular Ecology, Vol. 24, No. 20, 01.10.2015, p. 5145-5157.

Research output: Contribution to journalArticle

Main, Bradley ; Lee, Yoosook ; Collier, Travis C. ; Norris, Laura C. ; Brisco, Katherine ; Fofana, Abdrahamane ; Cornel, Anthony J. ; Lanzaro, Gregory C. / Complex genome evolution in Anopheles coluzzii associated with increased insecticide usage in Mali. In: Molecular Ecology. 2015 ; Vol. 24, No. 20. pp. 5145-5157.
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