Complete response of brain metastases to irinotecan-based chemotherapy

Rachel Chou; Allan Chen; Derick H Lau

doi:10.1016/j.jocn.2004.08.007

Complete response of brain metastases to irinotecan-based chemotherapy

Rachel Chou, Allan Chen, Derick H Lau

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Brain metastases occur in 15-20% of patients with cancer and are generally associated with an overall poor prognosis. Currently, radiotherapy and surgery are the mainstay of palliative therapy for patients with brain metastases, while the role of systemic chemotherapy remains uncertain. In this article, we report complete responses to irinotecan-based chemotherapy in three patients with brain metastases from parotid adenocarcinoma, esophageal adenocarcinoma and small cell lung cancer. Irinotecan-based chemotherapy may hold promise in treating patients with brain metastases. Further studies are warranted to confirm our observations.

Original language	English (US)
Pages (from-to)	242-245
Number of pages	4
Journal	Journal of Clinical Neuroscience
Volume	12
Issue number	3
DOIs	https://doi.org/10.1016/j.jocn.2004.08.007
State	Published - Apr 2005

Keywords

Brain metastases
Irinotecan
Whole brain radiation

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health
Neurology

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abstract = "Brain metastases occur in 15-20% of patients with cancer and are generally associated with an overall poor prognosis. Currently, radiotherapy and surgery are the mainstay of palliative therapy for patients with brain metastases, while the role of systemic chemotherapy remains uncertain. In this article, we report complete responses to irinotecan-based chemotherapy in three patients with brain metastases from parotid adenocarcinoma, esophageal adenocarcinoma and small cell lung cancer. Irinotecan-based chemotherapy may hold promise in treating patients with brain metastases. Further studies are warranted to confirm our observations.",

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AU - Chen, Allan

AU - Lau, Derick H

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N2 - Brain metastases occur in 15-20% of patients with cancer and are generally associated with an overall poor prognosis. Currently, radiotherapy and surgery are the mainstay of palliative therapy for patients with brain metastases, while the role of systemic chemotherapy remains uncertain. In this article, we report complete responses to irinotecan-based chemotherapy in three patients with brain metastases from parotid adenocarcinoma, esophageal adenocarcinoma and small cell lung cancer. Irinotecan-based chemotherapy may hold promise in treating patients with brain metastases. Further studies are warranted to confirm our observations.

AB - Brain metastases occur in 15-20% of patients with cancer and are generally associated with an overall poor prognosis. Currently, radiotherapy and surgery are the mainstay of palliative therapy for patients with brain metastases, while the role of systemic chemotherapy remains uncertain. In this article, we report complete responses to irinotecan-based chemotherapy in three patients with brain metastases from parotid adenocarcinoma, esophageal adenocarcinoma and small cell lung cancer. Irinotecan-based chemotherapy may hold promise in treating patients with brain metastases. Further studies are warranted to confirm our observations.

KW - Brain metastases

KW - Irinotecan

KW - Whole brain radiation

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Complete response of brain metastases to irinotecan-based chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

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