Complete heart block associated with lupus in a dog

R. Malik, P. Zunino, Geraldine B Hunt

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 5-year-old Poodle-cross was initially presented for exercise intolerance and difficulty in chewing and yawning. Some months later it acutely developed lethargy referable to complete heart block. Further investigations before and after permanent pacemaker implantation demonstrated Coombs-positive immune-mediated haemolytic anaemia, presumptive masticatory myositis and hypoadrenocorticism, suggesting the possibility of multisystem auto-immune disease. A diagnosis of systemic lupus erythematosus (SLE) was made based on these findings and a positive anti-nuclear antibody titre. It was thought that immune-mediated destruction of cardiac conduction tissues was responsible for the development of atrioventricular conduction block. Glucocorticoid deficiency was corrected using cortisone replacement therapy. SLE was controlled successfully for 10 months using azathioprine monotherapy until signs, subsequently shown to be due to subacute bacterial endocarditis, resulted in the death of the patient. Lupus should be considered as a potential underlying aetiology in dogs that develop heart block.

Original languageEnglish (US)
Pages (from-to)398-401
Number of pages4
JournalAustralian Veterinary Journal
Volume81
Issue number7
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

lupus erythematosus
Heart Block
Systemic Lupus Erythematosus
heart
Yawning
Subacute Bacterial Endocarditis
Dogs
hypoadrenocorticism
cortisone
myositis
Poodle (dog breed)
endocarditis
Lethargy
hemolytic anemia
Myositis
Atrioventricular Block
dogs
autoimmune diseases
Mastication
Hemolytic Anemia

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Complete heart block associated with lupus in a dog. / Malik, R.; Zunino, P.; Hunt, Geraldine B.

In: Australian Veterinary Journal, Vol. 81, No. 7, 2003, p. 398-401.

Research output: Contribution to journalArticle

Malik, R. ; Zunino, P. ; Hunt, Geraldine B. / Complete heart block associated with lupus in a dog. In: Australian Veterinary Journal. 2003 ; Vol. 81, No. 7. pp. 398-401.
@article{cfbf6726bfbc42f6b3b9385d177cfee0,
title = "Complete heart block associated with lupus in a dog",
abstract = "A 5-year-old Poodle-cross was initially presented for exercise intolerance and difficulty in chewing and yawning. Some months later it acutely developed lethargy referable to complete heart block. Further investigations before and after permanent pacemaker implantation demonstrated Coombs-positive immune-mediated haemolytic anaemia, presumptive masticatory myositis and hypoadrenocorticism, suggesting the possibility of multisystem auto-immune disease. A diagnosis of systemic lupus erythematosus (SLE) was made based on these findings and a positive anti-nuclear antibody titre. It was thought that immune-mediated destruction of cardiac conduction tissues was responsible for the development of atrioventricular conduction block. Glucocorticoid deficiency was corrected using cortisone replacement therapy. SLE was controlled successfully for 10 months using azathioprine monotherapy until signs, subsequently shown to be due to subacute bacterial endocarditis, resulted in the death of the patient. Lupus should be considered as a potential underlying aetiology in dogs that develop heart block.",
author = "R. Malik and P. Zunino and Hunt, {Geraldine B}",
year = "2003",
doi = "10.1111/j.1751-0813.2003.tb11544.x",
language = "English (US)",
volume = "81",
pages = "398--401",
journal = "Australian Veterinary Journal",
issn = "0005-0423",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Complete heart block associated with lupus in a dog

AU - Malik, R.

AU - Zunino, P.

AU - Hunt, Geraldine B

PY - 2003

Y1 - 2003

N2 - A 5-year-old Poodle-cross was initially presented for exercise intolerance and difficulty in chewing and yawning. Some months later it acutely developed lethargy referable to complete heart block. Further investigations before and after permanent pacemaker implantation demonstrated Coombs-positive immune-mediated haemolytic anaemia, presumptive masticatory myositis and hypoadrenocorticism, suggesting the possibility of multisystem auto-immune disease. A diagnosis of systemic lupus erythematosus (SLE) was made based on these findings and a positive anti-nuclear antibody titre. It was thought that immune-mediated destruction of cardiac conduction tissues was responsible for the development of atrioventricular conduction block. Glucocorticoid deficiency was corrected using cortisone replacement therapy. SLE was controlled successfully for 10 months using azathioprine monotherapy until signs, subsequently shown to be due to subacute bacterial endocarditis, resulted in the death of the patient. Lupus should be considered as a potential underlying aetiology in dogs that develop heart block.

AB - A 5-year-old Poodle-cross was initially presented for exercise intolerance and difficulty in chewing and yawning. Some months later it acutely developed lethargy referable to complete heart block. Further investigations before and after permanent pacemaker implantation demonstrated Coombs-positive immune-mediated haemolytic anaemia, presumptive masticatory myositis and hypoadrenocorticism, suggesting the possibility of multisystem auto-immune disease. A diagnosis of systemic lupus erythematosus (SLE) was made based on these findings and a positive anti-nuclear antibody titre. It was thought that immune-mediated destruction of cardiac conduction tissues was responsible for the development of atrioventricular conduction block. Glucocorticoid deficiency was corrected using cortisone replacement therapy. SLE was controlled successfully for 10 months using azathioprine monotherapy until signs, subsequently shown to be due to subacute bacterial endocarditis, resulted in the death of the patient. Lupus should be considered as a potential underlying aetiology in dogs that develop heart block.

UR - http://www.scopus.com/inward/record.url?scp=2342597791&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2342597791&partnerID=8YFLogxK

U2 - 10.1111/j.1751-0813.2003.tb11544.x

DO - 10.1111/j.1751-0813.2003.tb11544.x

M3 - Article

C2 - 15084050

AN - SCOPUS:2342597791

VL - 81

SP - 398

EP - 401

JO - Australian Veterinary Journal

JF - Australian Veterinary Journal

SN - 0005-0423

IS - 7

ER -