@article{b080d77c43dc4ff894293863896ce044,
title = "Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae",
abstract = "The 2,160,267 bp genome sequence of Streptococcus agalactiae, the leading cause of bacterial sepsis, pneumonia, and meningitis in neonates in the U.S. and Europe, is predicted to encode 2,175 genes. Genome comparisons among S. agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, and the other completely sequenced genomes identified genes specific to the streptococci and to S. agalactiae. These in silico analyses, combined with comparative genome hybridization experiments between the sequenced serotype V strain 2603 V/R and 19 S. agalactiae strains from several serotypes using whole-genome microarrays, revealed the genetic heterogeneity among S. agalactiae strains, even of the same serotype, and provided insights into the evolution of virulence mechanisms.",
author = "Herv{\'e} Tettelin and Vega Masignani and Cieslewicz, {Michael J.} and Eisen, {Jonathan A} and Scott Peterson and Wessels, {Michael R.} and Paulsen, {Ian T.} and Nelson, {Karen E.} and Immaculada Margarit and Read, {Timothy D.} and Madoff, {Lawrence C.} and Wolf, {Alex M.} and Beanan, {Maureen J.} and Brinkac, {Lauren M.} and Daugherty, {Sean C.} and DeBoy, {Robert T.} and Durkin, {A. Scott} and Kolonay, {James F.} and Ramana Madupu and Lewis, {Matthew R.} and Diana Radune and Fedorova, {Nadezhda B.} and David Scanlan and Hoda Khouri and Stephanie Mulligan and Carty, {Heather A.} and Cline, {Robin T.} and {Van Aken}, {Susan E.} and John Gill and Maria Scarselli and Marirosa Mora and Iacobini, {Emilia T.} and Cecilia Brettoni and Giuliano Galli and Massimo Mariani and Filippo Vegni and Domenico Maione and Daniela Rinaudo and Rino Rappuoli and Telford, {John L.} and Kasper, {Dennis L.} and Guido Grandi and Fraser, {Claire M.}",
year = "2002",
month = sep,
day = "17",
doi = "10.1073/pnas.182380799",
language = "English (US)",
volume = "99",
pages = "12391--12396",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "19",
}