Abstract
4-Hydroxy-3-(2′-pyridyl)coumarins (4) (R = 6-Cl, H, 6-NO2, 8-NO2) were prepared in moderate to good yields by the intramolecular nucleophilic aromatic substitution reaction of β-ketoesters (I) in refluxing xylenes; evidence for the reversible formation of benzo[c]quinolizinium III from I (X = 4-Cl), with eventual formation of 4 (R = 6-Cl), is also presented.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 639-640 |
| Number of pages | 2 |
| Journal | Chemical Communications |
| Issue number | 7 |
| State | Published - Apr 7 2001 |
ASJC Scopus subject areas
- Chemistry(all)
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Alonso, C., Olmstead, M. M., Nantz, M. H., & Kurth, M. J. (2001). Competitive intramolecular nucleophilic aromatic substitution: A new route to coumarins. Chemical Communications, (7), 639-640.