Competition and representation during memory retrieval: Roles of the prefrontal cortex and the posterior parietal cortex

Myeong Ho Sohn, Adam Goode, V. Andrew Stenger, Cameron S Carter, John R. Anderson

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

In this functional-MRI study we examined the hypothesis that the prefrontal cortex responds differently to the extent of competition during retrieval, whereas the parietal cortex is responsible for problem representation that should not be directly related to the competition. Participants mastered arbitrary person-location pairs, and their recognition memory was tested in a functional-MRI session. The pairs were constructed such that a person was associated with one, two, or three different locations and vice versa. The recognition time increased with the number of associations, reflecting increased competition. A confirmatory analysis of imaging data with prespecified prefrontal and parietal regions showed that, although both regions were highly involved during memory retrieval, only the prefrontal region responded to the levels of competition. This result was consistent with predictions of an information-processing model as well as with an exploratory identification of regions of interest.

Original languageEnglish (US)
Pages (from-to)7412-7417
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume100
Issue number12
DOIs
StatePublished - Jun 10 2003
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • General

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