Comparison of two intravenous anesthetic infusion regimens for alfaxalone in cats

Bruno H Pypendop, M. G. Ranasinghe, Kirby Pasloske

Research output: Contribution to journalArticle

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Abstract

Objective: To compare the performance of an alfaxalone constant rate intravenous (IV) infusion versus a 3-step IV infusion, both following a loading dose, for the maintenance of a target plasma alfaxalone concentration of 7.6 mg L–1 (effective plasma alfaxalone concentration for immobility in 99% of the population) in cats. Study design: Prospective randomized crossover study. Animals: A group of six healthy, adult male neutered cats. Methods: Catheters were placed in a jugular vein for blood sampling and in a medial saphenous vein for drug administration. An IV bolus of alfaxalone (2 mg kg–1) was administered, followed by either 0.2 mg kg−1 minute−1 for 240 minutes (single infusion; SI) or 0.4 mg kg−1 minute−1 for 10 minutes, then 0.3 mg kg−1 minute−1 for 30 minutes, and then 0.2 mg kg−1 minute−1 for 200 minutes (3-step infusion; 3-step). Plasma alfaxalone concentration was measured at six time points during the infusions. Measures of performance were calculated for each infusion regimen and compared using the paired Wilcoxon signed-rank test. Results: Median (range) absolute performance error, divergence, median prediction error and wobble were 15 (8–19)%, −8 (−12 to −6)% hour−1, −12 (−19 to −7)% and 10 (8–19)%, respectively, in the SI treatment, and 6 (2–16)%, 0 (−13 to 2)% hour−1, 1 (−16 to 4)% and 4 (3–6)% respectively, in the 3-step treatment and were significantly smaller in the 3-step treatment than in the SI treatment. Conclusion and clinical relevance: After IV administration of a bolus dose, a 3-step infusion regimen can better maintain stable plasma alfaxalone concentrations close to the target concentration than a single constant rate infusion.

Original languageEnglish (US)
JournalVeterinary Anaesthesia and Analgesia
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Intravenous Anesthetics
Intravenous Infusions
anesthetics
Cats
saphenous vein
cats
blood sampling
jugular vein
dosage
intravenous injection
catheters
experimental design
drugs
prediction
animals
Jugular Veins
testing
Saphenous Vein
Therapeutics
Nonparametric Statistics

Keywords

  • alfaxalone
  • cats
  • constant rate infusion

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparison of two intravenous anesthetic infusion regimens for alfaxalone in cats. / Pypendop, Bruno H; Ranasinghe, M. G.; Pasloske, Kirby.

In: Veterinary Anaesthesia and Analgesia, 01.01.2018.

Research output: Contribution to journalArticle

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abstract = "Objective: To compare the performance of an alfaxalone constant rate intravenous (IV) infusion versus a 3-step IV infusion, both following a loading dose, for the maintenance of a target plasma alfaxalone concentration of 7.6 mg L–1 (effective plasma alfaxalone concentration for immobility in 99{\%} of the population) in cats. Study design: Prospective randomized crossover study. Animals: A group of six healthy, adult male neutered cats. Methods: Catheters were placed in a jugular vein for blood sampling and in a medial saphenous vein for drug administration. An IV bolus of alfaxalone (2 mg kg–1) was administered, followed by either 0.2 mg kg−1 minute−1 for 240 minutes (single infusion; SI) or 0.4 mg kg−1 minute−1 for 10 minutes, then 0.3 mg kg−1 minute−1 for 30 minutes, and then 0.2 mg kg−1 minute−1 for 200 minutes (3-step infusion; 3-step). Plasma alfaxalone concentration was measured at six time points during the infusions. Measures of performance were calculated for each infusion regimen and compared using the paired Wilcoxon signed-rank test. Results: Median (range) absolute performance error, divergence, median prediction error and wobble were 15 (8–19){\%}, −8 (−12 to −6){\%} hour−1, −12 (−19 to −7){\%} and 10 (8–19){\%}, respectively, in the SI treatment, and 6 (2–16){\%}, 0 (−13 to 2){\%} hour−1, 1 (−16 to 4){\%} and 4 (3–6){\%} respectively, in the 3-step treatment and were significantly smaller in the 3-step treatment than in the SI treatment. Conclusion and clinical relevance: After IV administration of a bolus dose, a 3-step infusion regimen can better maintain stable plasma alfaxalone concentrations close to the target concentration than a single constant rate infusion.",
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N2 - Objective: To compare the performance of an alfaxalone constant rate intravenous (IV) infusion versus a 3-step IV infusion, both following a loading dose, for the maintenance of a target plasma alfaxalone concentration of 7.6 mg L–1 (effective plasma alfaxalone concentration for immobility in 99% of the population) in cats. Study design: Prospective randomized crossover study. Animals: A group of six healthy, adult male neutered cats. Methods: Catheters were placed in a jugular vein for blood sampling and in a medial saphenous vein for drug administration. An IV bolus of alfaxalone (2 mg kg–1) was administered, followed by either 0.2 mg kg−1 minute−1 for 240 minutes (single infusion; SI) or 0.4 mg kg−1 minute−1 for 10 minutes, then 0.3 mg kg−1 minute−1 for 30 minutes, and then 0.2 mg kg−1 minute−1 for 200 minutes (3-step infusion; 3-step). Plasma alfaxalone concentration was measured at six time points during the infusions. Measures of performance were calculated for each infusion regimen and compared using the paired Wilcoxon signed-rank test. Results: Median (range) absolute performance error, divergence, median prediction error and wobble were 15 (8–19)%, −8 (−12 to −6)% hour−1, −12 (−19 to −7)% and 10 (8–19)%, respectively, in the SI treatment, and 6 (2–16)%, 0 (−13 to 2)% hour−1, 1 (−16 to 4)% and 4 (3–6)% respectively, in the 3-step treatment and were significantly smaller in the 3-step treatment than in the SI treatment. Conclusion and clinical relevance: After IV administration of a bolus dose, a 3-step infusion regimen can better maintain stable plasma alfaxalone concentrations close to the target concentration than a single constant rate infusion.

AB - Objective: To compare the performance of an alfaxalone constant rate intravenous (IV) infusion versus a 3-step IV infusion, both following a loading dose, for the maintenance of a target plasma alfaxalone concentration of 7.6 mg L–1 (effective plasma alfaxalone concentration for immobility in 99% of the population) in cats. Study design: Prospective randomized crossover study. Animals: A group of six healthy, adult male neutered cats. Methods: Catheters were placed in a jugular vein for blood sampling and in a medial saphenous vein for drug administration. An IV bolus of alfaxalone (2 mg kg–1) was administered, followed by either 0.2 mg kg−1 minute−1 for 240 minutes (single infusion; SI) or 0.4 mg kg−1 minute−1 for 10 minutes, then 0.3 mg kg−1 minute−1 for 30 minutes, and then 0.2 mg kg−1 minute−1 for 200 minutes (3-step infusion; 3-step). Plasma alfaxalone concentration was measured at six time points during the infusions. Measures of performance were calculated for each infusion regimen and compared using the paired Wilcoxon signed-rank test. Results: Median (range) absolute performance error, divergence, median prediction error and wobble were 15 (8–19)%, −8 (−12 to −6)% hour−1, −12 (−19 to −7)% and 10 (8–19)%, respectively, in the SI treatment, and 6 (2–16)%, 0 (−13 to 2)% hour−1, 1 (−16 to 4)% and 4 (3–6)% respectively, in the 3-step treatment and were significantly smaller in the 3-step treatment than in the SI treatment. Conclusion and clinical relevance: After IV administration of a bolus dose, a 3-step infusion regimen can better maintain stable plasma alfaxalone concentrations close to the target concentration than a single constant rate infusion.

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