COMPARISON OF TRANSCOLONIC 123I‐IODOAMPHETAMINE AND PORTAL VEIN INJECTION OF 99mTc‐MACROAGGREGATED ALBUMIN SHUNT FRACTION CALCU‐LATIONS IN EXPERIMENTAL DOGS WITH ACQUIRED POR‐TOSYSTEMIC SHUNTS

Philip D. Koblik, Chi‐Kwan ‐K Yen, Jan Komtebedde, William J. Hornof, Peter F Moore, Paul E. Fisher

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Shunt fraction was determined using transcolonic 123I‐iodoamphetamine (IMP) and portal vein injection of 99mTc‐macroaggregated albumin (MAA) in a group of eight dogs with chronic cirrhosis and acquired portosystemic shunts subsequent to total common bile duct ligation. Hepatic parenchymal damage was confirmed by alterations in liver function tests and liver histology. Seven of the eight dogs developed portal hypertension and had angiographic evidence of hepatofugal portal blood flow with multiple peripheral portosystemic anastomoses. Shunt fractions determined in the seven dogs with shunts varied from 39 to 100 using IMP and 45 to 93 using MAA. The remaining dog had normal portal pressure, a normal portal angiogram, and normal IMP and MAA scintigraphic studies. There was an excellent correlation between the two methods of shunt fraction calculation (R2= 0.98) and the line of regression was not significantly different from unity (IMP = 1.09 × MAA ‐ 0.03).

Original languageEnglish (US)
Pages (from-to)170-174
Number of pages5
JournalVeterinary Radiology
Volume31
Issue number4
DOIs
StatePublished - 1990

Keywords

  • dog
  • portosystemic shunt
  • transcolonic iodoamphetamine scintigraphy

ASJC Scopus subject areas

  • veterinary(all)

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