Comparison of topical administration of clotrimazole through surgically placed versus nonsurgically placed catheters for treatment of nasal aspergillosis in dogs: 60 cases (1990-1996)

Kyle G. Mathews, Autumn P. Davidson, Philip D. Koblik, Elisabeth F. Richardson, Jan Komtebedde, Demosthenes Pappagianis, Richard F. Hector, Philip H Kass

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66 Citations (Scopus)

Abstract

Objective - To examine the clinical response to topical administration of clotrimazole in dogs with nasal aspergillosis, to compare effect of surgically placed versus nonsurgically placed catheters used for administration on outcome, and to examine whether subjective scoring of computed tomographic images can predict outcome. Design - Retrospective case series. Animals - 60 dogs with nasal aspergillosis. Procedure - Information including signalment, history, diagnostics, treatment method, and outcome was retrieved from medical records of dogs with nasal aspergillosis treated between 1990 and 1996 at the University of California School of Veterinary Medicine or cooperating referral practices. Final outcome was determined by telephone conversations with owners and referring veterinarians. Images obtained before treatment were subjectively assessed to develop an algorithm for predicting outcome. Results - Clotrimazole solution (1%) was infused during a 1-hour period via catheters surgically placed in the frontal sinus and nose (27 dogs) and via nonsurgically period catheters in the nose (18). An additional 15 dogs received 2 to 4 infusions by either route. Topical administration of clotrimazole resulted in resolution of clinical disease in 65% of dogs after 1 treatment and 87% of dogs after one or more treatments. The scoring system correctly classified dogs with unfavorable and favorable responses 71 to 78% and 79 to 93% of the time, respectively. Clinical Implications - Topical administration of clotrimazole, using either technique, was an effective treatment for nasal aspergillosis in dogs. Use of non-invasive intranasal infusion of clotrimazole eliminated the need for surgical trephination of frontal sinuses in many dogs and was associated with fewer complications.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalJournal of the American Veterinary Medical Association
Volume213
Issue number4
StatePublished - Aug 15 1998

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clotrimazole
Clotrimazole
Topical Administration
Aspergillosis
aspergillosis
Nose
catheters
Catheters
Dogs
dogs
Therapeutics
Frontal Sinus
sinuses
Trephining
Veterinary Medicine
Veterinarians
Telephone
veterinary medicine
Medical Records
veterinarians

ASJC Scopus subject areas

  • veterinary(all)

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Comparison of topical administration of clotrimazole through surgically placed versus nonsurgically placed catheters for treatment of nasal aspergillosis in dogs : 60 cases (1990-1996). / Mathews, Kyle G.; Davidson, Autumn P.; Koblik, Philip D.; Richardson, Elisabeth F.; Komtebedde, Jan; Pappagianis, Demosthenes; Hector, Richard F.; Kass, Philip H.

In: Journal of the American Veterinary Medical Association, Vol. 213, No. 4, 15.08.1998, p. 501-506.

Research output: Contribution to journalArticle

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abstract = "Objective - To examine the clinical response to topical administration of clotrimazole in dogs with nasal aspergillosis, to compare effect of surgically placed versus nonsurgically placed catheters used for administration on outcome, and to examine whether subjective scoring of computed tomographic images can predict outcome. Design - Retrospective case series. Animals - 60 dogs with nasal aspergillosis. Procedure - Information including signalment, history, diagnostics, treatment method, and outcome was retrieved from medical records of dogs with nasal aspergillosis treated between 1990 and 1996 at the University of California School of Veterinary Medicine or cooperating referral practices. Final outcome was determined by telephone conversations with owners and referring veterinarians. Images obtained before treatment were subjectively assessed to develop an algorithm for predicting outcome. Results - Clotrimazole solution (1{\%}) was infused during a 1-hour period via catheters surgically placed in the frontal sinus and nose (27 dogs) and via nonsurgically period catheters in the nose (18). An additional 15 dogs received 2 to 4 infusions by either route. Topical administration of clotrimazole resulted in resolution of clinical disease in 65{\%} of dogs after 1 treatment and 87{\%} of dogs after one or more treatments. The scoring system correctly classified dogs with unfavorable and favorable responses 71 to 78{\%} and 79 to 93{\%} of the time, respectively. Clinical Implications - Topical administration of clotrimazole, using either technique, was an effective treatment for nasal aspergillosis in dogs. Use of non-invasive intranasal infusion of clotrimazole eliminated the need for surgical trephination of frontal sinuses in many dogs and was associated with fewer complications.",
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