Comparison of the nucleotide sequences of diabetogenic and nondiabetogenic encephalomyocarditis virus

Stuart H Cohen, Robert K. Naviaux, Kurt M. Vanden Brink, George W. Jordan

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The nucleotide sequences of a diabetogenic variant of encephalomyocarditis (EMC) virus (D variant, ifp- phenotype) and a nondiabetogenic variant of EMC virus (B variant, ifp+ phenotype) have been compared. These variants differ at eight sites. The poly(C) tract of EMC-B is three bases shorter than that of EMC-D. Of the seven sites at which nucleotide substitutions were confirmed using RNA templates, four resulted in amino acid changes in three different proteins, the leader peptide, t B (VP2), and 1D (VPI ). The biological significance of these differences can now be investigated.

Original languageEnglish (US)
Pages (from-to)603-607
Number of pages5
JournalVirology
Volume166
Issue number2
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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