Abstract
We studied the intrinsic tyrosine kinase activity and substrate specificity of c-Abl and Bcr-Abl protein tyrosine kinases (PTKs) using the peptide substrates discovered from a synthetic combinatorial peptide library. Our data indicate that the phosphorylation of these peptides by Bcr-Abl was consistently stronger than that by c-Abl. Bcr-Abl also showed substrate preference towards those peptides with one or more positive charges.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2279-2284 |
| Number of pages | 6 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 8 |
| Issue number | 17 |
| DOIs | |
| State | Published - Sep 8 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Comparison of the intrinsic kinase activity and substrate specificity of c-Abl and Bcr-Abl. / Wu, Jinzi J.; Phan, Hoang; Lam, Kit.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 8, No. 17, 08.09.1998, p. 2279-2284.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Comparison of the intrinsic kinase activity and substrate specificity of c-Abl and Bcr-Abl
AU - Wu, Jinzi J.
AU - Phan, Hoang
AU - Lam, Kit
PY - 1998/9/8
Y1 - 1998/9/8
N2 - We studied the intrinsic tyrosine kinase activity and substrate specificity of c-Abl and Bcr-Abl protein tyrosine kinases (PTKs) using the peptide substrates discovered from a synthetic combinatorial peptide library. Our data indicate that the phosphorylation of these peptides by Bcr-Abl was consistently stronger than that by c-Abl. Bcr-Abl also showed substrate preference towards those peptides with one or more positive charges.
AB - We studied the intrinsic tyrosine kinase activity and substrate specificity of c-Abl and Bcr-Abl protein tyrosine kinases (PTKs) using the peptide substrates discovered from a synthetic combinatorial peptide library. Our data indicate that the phosphorylation of these peptides by Bcr-Abl was consistently stronger than that by c-Abl. Bcr-Abl also showed substrate preference towards those peptides with one or more positive charges.
UR - http://www.scopus.com/inward/record.url?scp=0032497398&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032497398&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(98)00413-2
DO - 10.1016/S0960-894X(98)00413-2
M3 - Article
C2 - 9873528
AN - SCOPUS:0032497398
VL - 8
SP - 2279
EP - 2284
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 17
ER -