Comparison of the effects of Clostridium perfringens type D culture supernates in ligated intestinal loops of goats and sheep

Francisco A Uzal, M. Ghoddusi, W. R. Kelly, M. Rozmanec

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Abstract

The effects of Clostridium perfringens type D culture supernates were compared in ligated loops of the small intestine (ileum) and colon of four goat kids and four lambs, the loops being examined histopathologically and electron microscopically 7 h after inoculation. No lesions were observed in the small intestine of any animal, or in control colonic loops. In the caprine and ovine colonic loops treated with culture supernates, most goblet cells were empty and the lumina contained a layer of mucus, polymorphonuclear leucocytes, bacteria and sloughed epithelial cells. The apical cytoplasm of the superficial epithelial cells was lost. Moderate oedema was observed in the submucosa and muscular layer. The colonic lesions were more severe in kids than in lambs. No changes were seen in vascular endothelial cells in any loop.

Original languageEnglish (US)
Pages (from-to)127-138
Number of pages12
JournalJournal of Comparative Pathology
Volume121
Issue number2
DOIs
StatePublished - Aug 1999
Externally publishedYes

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ASJC Scopus subject areas

  • Animal Science and Zoology

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