Comparison of the effect of temafloxacin, ciprofloxacin, or placebo on cerebral blood flow, glucose, and oxygen metabolism in healthy subjects by means of positron emission tomography

Edward M. Bednarczyk, Jeffrey A. Green, A. Dennis Nelson, Gregory A. Leisure, Dana Little, Lee P. Adler, Marc S. Berridge, Edward A Panacek, Floro D. Miraldi

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Study objective: To determine the cause of the central nervous system effect of the fluorinated quinolones temafloxacin and ciprofloxacin by measuring cerebral blood flow and metabolism by use of positron emission tomography. Design: This was a prospective, randomized, double-blind, placebo-controlled study. Patients: The patients were 13 healthy, nonsmoking volunteers whose ages ranged from 18 to 40 years. Results: We measured brain blood flow and metabolism by use of positron emission tomography before and after a five-dose course of 750 mg ciprofloxacin, 600 mg temafloxacin, or placebo given every 12 hours. Placebo Ciprofloxacin Temafloxacin Baseline * (n = 4) † (n = 5) † (n = 3) † Blood flow (ml/min/100 gm) 50.3 ± 5.9 -1.5 ± 1.4 -9.7 ± 2.5 ‡ 3.8 ± 1.5 Glucose metabolism (mg/min/100 gm) 5.3 ± 1.1 0.43 ± 0.3 -1.1 ± 0.4 -0.7 ± 0.5 O2 Metabolism (ml/min/100 gm) 3.8 ± 1.4 0.13 ± 0.9 -1.6 ± 0.9 -0.4 ± 1.9 O2 Extraction fraction 0.37 ± 0.2 -0.05 ± 0.1 -0.1 ± 0.06 -0.04 ± 0.04 * Baseline data mean ± SEM, n = 12. † Values expressed as mean change ± SEM. ‡ p < 0.05, paired t test, compared with baseline, compared with other treatments, one-way ANOVA. Quinolone administration produced no significant effect on visual (qualitative) reading of the positron emission tomography scans. Conclusions: We conclude that short-term administration of temafloxacin, ciprofloxacin, or placebo does not significantly alter cerebral glucose or oxygen metabolism. Subjects treated with ciprofloxacin demonstrated a significant decrease in brain blood flow compared with baseline and with temafloxacin- or placebo-treated subjects.

Original languageEnglish (US)
Pages (from-to)165-171
Number of pages7
JournalClinical Pharmacology and Therapeutics
Volume50
Issue number2
StatePublished - Aug 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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