Comparison of sympathetic skin response with quantitative sudomotor axon reflex test in diabetic neuropathy

Ricardo A Maselli, J. B. Jaspan, B. C. Soliven, A. J. Green, J. P. Spire, B. G W Arnason

Research output: Contribution to journalArticle

84 Scopus citations

Abstract

The sympathetic skin response (SSR), the quantitative sudomotor axon reflex test (Q-SART), and cardiac beat-to-beat variability with respiration as measured by the expiratory/inspiratory ratio (E/I ratio) were studied in 39 patients with diabetic neuropathy of whom 33 also had one or more symptoms of autonomic involvement. In the lower extremities 87% of the patients with an absent SSR had an abnormal Q-SART (P < 0.001), and 81% of patients with the SSR present had a normal Q-SART (P < 0.02). The E/I ratio was abnormal in all but one of 23 patients with an absent SSR in the foot, and a normal E/I ratio was present only in those patients (n = 7) with the SSR present in hand and foot, and in an eighth patient who had SSR absent in the foot and present in the hand. A similar correlation was found between the E/I ratio and the Q-SART in the foot, although 4 of 25 patients with an abnormal foot Q-SART had a normal E/I ratio. We conclude that the concordance of results of the SSR and Q-SART supports the combined use of these tests to uncover early distal sympathetic failure in diabetic neuropathy.

Original languageEnglish (US)
Pages (from-to)420-423
Number of pages4
JournalMuscle and Nerve
Volume12
Issue number5
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Maselli, R. A., Jaspan, J. B., Soliven, B. C., Green, A. J., Spire, J. P., & Arnason, B. G. W. (1989). Comparison of sympathetic skin response with quantitative sudomotor axon reflex test in diabetic neuropathy. Muscle and Nerve, 12(5), 420-423.