Comparison of survival between cerebellar and supratentorial glioblastoma patients: Surveillance, epidemiology, and end results (SEER) analysis

Sunil Jeswani, Miriam A Nuno, Vanessa Folkerts, Debraj Mukherjee, Keith L. Black, Chirag G. Patil

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Cerebellar glioblastoma multiforme (cGBM) is rare, and although there is a general belief that these tumors have a worse prognosis than supratentorial GBM (sGBM), few studies have been published to support this belief. Objective: To investigate the effect of cerebellar location on survival through a casecontrol design comparing overall survival time of cGBM and sGBM patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify 132 patients with cGBM (1973-2008). Each cGBM patient was matched with an sGBM patient from among 20 848 sGBM patients on the basis of age, extent of resection, decade of diagnosis, and radiation therapy using propensity score matching. Results: Within the cGBM, 37% were older than 65 years of age, 62% were men, and 87% were white. Most patients underwent surgery and radiation (74%), whereas only 26% underwent surgical resection only. The median survival time for the cGBM and sGBM matched cohort was 8 months; however, the survival distributions differed (log-rank P =.04). Survival time for cGBM vs sGBM at 2 years was 21.5% vs 8.0%, and 12.7% vs 5.3% at 3 years. Multivariate analysis of survival among cGBM patients showed that younger age (P,.0001) and having radiation therapy (P,.0001) were significantly associated with reduced hazard of mortality. Among all patients, multivariate analysis showed that tumor location (P =.03), age (P,.0001), tumor size (P =.009), radiation (P,.0001), and resection (P,.0001) were associated with survival time in the unmatched cohort. Conclusion: Median survival time for cGBM and sGBM patients was 8 months, but cGBM patients had a survival time advantage as the study progressed. These findings suggest that cGBM patients should be treated as aggressively as sGBM patients with surgical resection and radiation therapy.

Original languageEnglish (US)
Pages (from-to)240-246
Number of pages7
JournalNeurosurgery
Volume73
Issue number2
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

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Glioblastoma
Epidemiology
Survival
Radiotherapy
Multivariate Analysis
Radiation
Neoplasms
Propensity Score
Registries

Keywords

  • Case-control study
  • Cerebellar glioblastoma
  • Gross total resection
  • Overall survival time
  • Radiation
  • Supratentorial glioblastoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Comparison of survival between cerebellar and supratentorial glioblastoma patients : Surveillance, epidemiology, and end results (SEER) analysis. / Jeswani, Sunil; Nuno, Miriam A; Folkerts, Vanessa; Mukherjee, Debraj; Black, Keith L.; Patil, Chirag G.

In: Neurosurgery, Vol. 73, No. 2, 01.08.2013, p. 240-246.

Research output: Contribution to journalArticle

Jeswani, Sunil ; Nuno, Miriam A ; Folkerts, Vanessa ; Mukherjee, Debraj ; Black, Keith L. ; Patil, Chirag G. / Comparison of survival between cerebellar and supratentorial glioblastoma patients : Surveillance, epidemiology, and end results (SEER) analysis. In: Neurosurgery. 2013 ; Vol. 73, No. 2. pp. 240-246.
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abstract = "Background: Cerebellar glioblastoma multiforme (cGBM) is rare, and although there is a general belief that these tumors have a worse prognosis than supratentorial GBM (sGBM), few studies have been published to support this belief. Objective: To investigate the effect of cerebellar location on survival through a casecontrol design comparing overall survival time of cGBM and sGBM patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify 132 patients with cGBM (1973-2008). Each cGBM patient was matched with an sGBM patient from among 20 848 sGBM patients on the basis of age, extent of resection, decade of diagnosis, and radiation therapy using propensity score matching. Results: Within the cGBM, 37{\%} were older than 65 years of age, 62{\%} were men, and 87{\%} were white. Most patients underwent surgery and radiation (74{\%}), whereas only 26{\%} underwent surgical resection only. The median survival time for the cGBM and sGBM matched cohort was 8 months; however, the survival distributions differed (log-rank P =.04). Survival time for cGBM vs sGBM at 2 years was 21.5{\%} vs 8.0{\%}, and 12.7{\%} vs 5.3{\%} at 3 years. Multivariate analysis of survival among cGBM patients showed that younger age (P,.0001) and having radiation therapy (P,.0001) were significantly associated with reduced hazard of mortality. Among all patients, multivariate analysis showed that tumor location (P =.03), age (P,.0001), tumor size (P =.009), radiation (P,.0001), and resection (P,.0001) were associated with survival time in the unmatched cohort. Conclusion: Median survival time for cGBM and sGBM patients was 8 months, but cGBM patients had a survival time advantage as the study progressed. These findings suggest that cGBM patients should be treated as aggressively as sGBM patients with surgical resection and radiation therapy.",
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T1 - Comparison of survival between cerebellar and supratentorial glioblastoma patients

T2 - Surveillance, epidemiology, and end results (SEER) analysis

AU - Jeswani, Sunil

AU - Nuno, Miriam A

AU - Folkerts, Vanessa

AU - Mukherjee, Debraj

AU - Black, Keith L.

AU - Patil, Chirag G.

PY - 2013/8/1

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N2 - Background: Cerebellar glioblastoma multiforme (cGBM) is rare, and although there is a general belief that these tumors have a worse prognosis than supratentorial GBM (sGBM), few studies have been published to support this belief. Objective: To investigate the effect of cerebellar location on survival through a casecontrol design comparing overall survival time of cGBM and sGBM patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify 132 patients with cGBM (1973-2008). Each cGBM patient was matched with an sGBM patient from among 20 848 sGBM patients on the basis of age, extent of resection, decade of diagnosis, and radiation therapy using propensity score matching. Results: Within the cGBM, 37% were older than 65 years of age, 62% were men, and 87% were white. Most patients underwent surgery and radiation (74%), whereas only 26% underwent surgical resection only. The median survival time for the cGBM and sGBM matched cohort was 8 months; however, the survival distributions differed (log-rank P =.04). Survival time for cGBM vs sGBM at 2 years was 21.5% vs 8.0%, and 12.7% vs 5.3% at 3 years. Multivariate analysis of survival among cGBM patients showed that younger age (P,.0001) and having radiation therapy (P,.0001) were significantly associated with reduced hazard of mortality. Among all patients, multivariate analysis showed that tumor location (P =.03), age (P,.0001), tumor size (P =.009), radiation (P,.0001), and resection (P,.0001) were associated with survival time in the unmatched cohort. Conclusion: Median survival time for cGBM and sGBM patients was 8 months, but cGBM patients had a survival time advantage as the study progressed. These findings suggest that cGBM patients should be treated as aggressively as sGBM patients with surgical resection and radiation therapy.

AB - Background: Cerebellar glioblastoma multiforme (cGBM) is rare, and although there is a general belief that these tumors have a worse prognosis than supratentorial GBM (sGBM), few studies have been published to support this belief. Objective: To investigate the effect of cerebellar location on survival through a casecontrol design comparing overall survival time of cGBM and sGBM patients. Methods: The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify 132 patients with cGBM (1973-2008). Each cGBM patient was matched with an sGBM patient from among 20 848 sGBM patients on the basis of age, extent of resection, decade of diagnosis, and radiation therapy using propensity score matching. Results: Within the cGBM, 37% were older than 65 years of age, 62% were men, and 87% were white. Most patients underwent surgery and radiation (74%), whereas only 26% underwent surgical resection only. The median survival time for the cGBM and sGBM matched cohort was 8 months; however, the survival distributions differed (log-rank P =.04). Survival time for cGBM vs sGBM at 2 years was 21.5% vs 8.0%, and 12.7% vs 5.3% at 3 years. Multivariate analysis of survival among cGBM patients showed that younger age (P,.0001) and having radiation therapy (P,.0001) were significantly associated with reduced hazard of mortality. Among all patients, multivariate analysis showed that tumor location (P =.03), age (P,.0001), tumor size (P =.009), radiation (P,.0001), and resection (P,.0001) were associated with survival time in the unmatched cohort. Conclusion: Median survival time for cGBM and sGBM patients was 8 months, but cGBM patients had a survival time advantage as the study progressed. These findings suggest that cGBM patients should be treated as aggressively as sGBM patients with surgical resection and radiation therapy.

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KW - Cerebellar glioblastoma

KW - Gross total resection

KW - Overall survival time

KW - Radiation

KW - Supratentorial glioblastoma

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