Abstract
Statistical reconstruction methods based on the penalized maximum likelihood (or maximum a posteriori) principle have gained increasing attention in emission tomography. Fessler and Rogers have shown that the penalized maximum likelihood reconstruction with a conventional quadratic penalty results in anisotropic point spread functions (PSFs). Several approaches have been developed to design modified penalty functions to achieve isotropic PSFs. While an image with an Isotropic PSF may be useful in some situations, its performance on clinical detection and quantitation tasks is unknown. In this paper, we compare the task performances using computer simulations. The lesion detectability is measured by a channelized Hotelling observer. The quantitation is evaluated by the bias and variance. The results show that reconstructions with an isotropic PSF may not be suitable for lesion detection and quantitation.
| Original language | English (US) |
|---|---|
| Title of host publication | IEEE Nuclear Science Symposium Conference Record |
| Editors | J.A. Seibert |
| Pages | 3624-3628 |
| Number of pages | 5 |
| Volume | 6 |
| State | Published - 2004 |
| Event | 2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors - Rome, Italy Duration: Oct 16 2004 → Oct 22 2004 |
Other
| Other | 2004 Nuclear Science Symposium, Medical Imaging Conference, Symposium on Nuclear Power Systems and the 14th International Workshop on Room Temperature Semiconductor X- and Gamma- Ray Detectors |
|---|---|
| Country | Italy |
| City | Rome |
| Period | 10/16/04 → 10/22/04 |
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ASJC Scopus subject areas
- Computer Vision and Pattern Recognition
- Industrial and Manufacturing Engineering
Cite this
Comparison of statistical reconstructions with isotropic and anisotropic resolution. / Qi, Jinyi.
IEEE Nuclear Science Symposium Conference Record. ed. / J.A. Seibert. Vol. 6 2004. p. 3624-3628 M9-291.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Comparison of statistical reconstructions with isotropic and anisotropic resolution
AU - Qi, Jinyi
PY - 2004
Y1 - 2004
N2 - Statistical reconstruction methods based on the penalized maximum likelihood (or maximum a posteriori) principle have gained increasing attention in emission tomography. Fessler and Rogers have shown that the penalized maximum likelihood reconstruction with a conventional quadratic penalty results in anisotropic point spread functions (PSFs). Several approaches have been developed to design modified penalty functions to achieve isotropic PSFs. While an image with an Isotropic PSF may be useful in some situations, its performance on clinical detection and quantitation tasks is unknown. In this paper, we compare the task performances using computer simulations. The lesion detectability is measured by a channelized Hotelling observer. The quantitation is evaluated by the bias and variance. The results show that reconstructions with an isotropic PSF may not be suitable for lesion detection and quantitation.
AB - Statistical reconstruction methods based on the penalized maximum likelihood (or maximum a posteriori) principle have gained increasing attention in emission tomography. Fessler and Rogers have shown that the penalized maximum likelihood reconstruction with a conventional quadratic penalty results in anisotropic point spread functions (PSFs). Several approaches have been developed to design modified penalty functions to achieve isotropic PSFs. While an image with an Isotropic PSF may be useful in some situations, its performance on clinical detection and quantitation tasks is unknown. In this paper, we compare the task performances using computer simulations. The lesion detectability is measured by a channelized Hotelling observer. The quantitation is evaluated by the bias and variance. The results show that reconstructions with an isotropic PSF may not be suitable for lesion detection and quantitation.
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M3 - Conference contribution
VL - 6
SP - 3624
EP - 3628
BT - IEEE Nuclear Science Symposium Conference Record
A2 - Seibert, J.A.
ER -