Comparison of serum immunoglobulin G half-life in dairy calves fed colostrum, colostrum replacer or administered with intravenous bovine plasma

Jacob M. Murphy, Jill V. Hagey, Munashe Chigerwe

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In calves, passive immunity of immunoglobulins can be acquired through ingestion of colostrum or colostrum replacers. Plasma can been used to supplement immunoglobulins in healthy or sick calves. Serum half-life of colostral derived immuglobulin G (IgG) is estimated to be 20 days. Half-life of IgG is important in determining response to antigens and timing of vaccination in calves. To date studies evaluating half-life of colostrum replacer or plasma derived IgG are lacking. The objectives of this study were to compare the serum half-life of IgG derived from colostrum, colostrum replacer and plasma in dairy calves reared up to 35 days of age. Thirty Jersey calves were randomly assigned to receive colostrum or colostrum replacer by oroesophageal tubing or plasma by intravenous administration. Serum samples were collected at 2, 5, 7, 10, 14, 21, 28 and 35 days. Serum IgG concentrations were determined by radial immunodiffusion. The results indicated that half-life for IgG in colostrum fed (28.5 days) or plasma transfused calves (27.3 days) was longer than colostrum replacer fed calves (19.1 days). Further studies are required to evaluate pathogen specific immunoglobulins in order to recommend vaccination timing in calves fed colostrum replacers.

Original languageEnglish (US)
Pages (from-to)233-237
Number of pages5
JournalVeterinary Immunology and Immunopathology
Volume158
Issue number3-4
DOIs
StatePublished - Apr 15 2014

Fingerprint

Colostrum
dairy calves
immunoglobulin G
colostrum
half life
Half-Life
Immunoglobulin G
cattle
Serum
calves
immunoglobulins
Immunoglobulins
Vaccination
vaccination
passive immunity
Immunodiffusion
Jersey
intravenous injection
Intravenous Administration
Immunity

Keywords

  • Calf
  • Colostrum
  • Colostrum replacer
  • Half-life
  • Immunoglobulin

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

Cite this

Comparison of serum immunoglobulin G half-life in dairy calves fed colostrum, colostrum replacer or administered with intravenous bovine plasma. / Murphy, Jacob M.; Hagey, Jill V.; Chigerwe, Munashe.

In: Veterinary Immunology and Immunopathology, Vol. 158, No. 3-4, 15.04.2014, p. 233-237.

Research output: Contribution to journalArticle

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