Comparison of serum and urinary concentrations of clenbuterol with and without concomitant administration of furosemide in horses

Noah D. Cohen, Zonghui Hu, Scott D Stanley, Naisyin Wang, Peter Weinstein

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Furosemide is frequently used to control or prevent exercise-induced pulmonary hemorrhage in performance horses. The bronchodilating agent clenbuterol is also commonly used as a treatment for inflammatory airway disease in performance horses. Use of both medications is regulated by many racing authorities. The effects of concomitant administration of furosemide and clenbuterol on the pharmacokinetics of clenbuterol have not been well characterized. A study was designed to evaluate the influence of furosemide on serum and urine concentrations of clenbuterol after oral administration of clenbuterol and intravenous administration of furosemide in horses. Results indicated that urinary concentrations of clenbuterol in horses treated concomitantly with furosemide and clenbuterol were increased, whereas serum concentrations of the drug were decreased. These effects persisted during the study period and varied among horses.

Original languageEnglish (US)
JournalVeterinary Therapeutics
Volume3
Issue number3
StatePublished - 2002
Externally publishedYes

Fingerprint

Clenbuterol
clenbuterol
furosemide
Furosemide
Horses
horses
Serum
bronchodilators
intravenous injection
Intravenous Administration
oral administration
pharmacokinetics
drug therapy
hemorrhage
Oral Administration
exercise
urine
Pharmacokinetics
lungs
Urine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparison of serum and urinary concentrations of clenbuterol with and without concomitant administration of furosemide in horses. / Cohen, Noah D.; Hu, Zonghui; Stanley, Scott D; Wang, Naisyin; Weinstein, Peter.

In: Veterinary Therapeutics, Vol. 3, No. 3, 2002.

Research output: Contribution to journalArticle

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