Abstract
Furosemide is frequently used to control or prevent exercise-induced pulmonary hemorrhage in performance horses. The bronchodilating agent clenbuterol is also commonly used as a treatment for inflammatory airway disease in performance horses. Use of both medications is regulated by many racing authorities. The effects of concomitant administration of furosemide and clenbuterol on the pharmacokinetics of clenbuterol have not been well characterized. A study was designed to evaluate the influence of furosemide on serum and urine concentrations of clenbuterol after oral administration of clenbuterol and intravenous administration of furosemide in horses. Results indicated that urinary concentrations of clenbuterol in horses treated concomitantly with furosemide and clenbuterol were increased, whereas serum concentrations of the drug were decreased. These effects persisted during the study period and varied among horses.
| Original language | English (US) |
|---|---|
| Journal | Veterinary Therapeutics |
| Volume | 3 |
| Issue number | 3 |
| State | Published - 2002 |
| Externally published | Yes |
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ASJC Scopus subject areas
- veterinary(all)
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Comparison of serum and urinary concentrations of clenbuterol with and without concomitant administration of furosemide in horses. / Cohen, Noah D.; Hu, Zonghui; Stanley, Scott D; Wang, Naisyin; Weinstein, Peter.
In: Veterinary Therapeutics, Vol. 3, No. 3, 2002.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Comparison of serum and urinary concentrations of clenbuterol with and without concomitant administration of furosemide in horses
AU - Cohen, Noah D.
AU - Hu, Zonghui
AU - Stanley, Scott D
AU - Wang, Naisyin
AU - Weinstein, Peter
PY - 2002
Y1 - 2002
N2 - Furosemide is frequently used to control or prevent exercise-induced pulmonary hemorrhage in performance horses. The bronchodilating agent clenbuterol is also commonly used as a treatment for inflammatory airway disease in performance horses. Use of both medications is regulated by many racing authorities. The effects of concomitant administration of furosemide and clenbuterol on the pharmacokinetics of clenbuterol have not been well characterized. A study was designed to evaluate the influence of furosemide on serum and urine concentrations of clenbuterol after oral administration of clenbuterol and intravenous administration of furosemide in horses. Results indicated that urinary concentrations of clenbuterol in horses treated concomitantly with furosemide and clenbuterol were increased, whereas serum concentrations of the drug were decreased. These effects persisted during the study period and varied among horses.
AB - Furosemide is frequently used to control or prevent exercise-induced pulmonary hemorrhage in performance horses. The bronchodilating agent clenbuterol is also commonly used as a treatment for inflammatory airway disease in performance horses. Use of both medications is regulated by many racing authorities. The effects of concomitant administration of furosemide and clenbuterol on the pharmacokinetics of clenbuterol have not been well characterized. A study was designed to evaluate the influence of furosemide on serum and urine concentrations of clenbuterol after oral administration of clenbuterol and intravenous administration of furosemide in horses. Results indicated that urinary concentrations of clenbuterol in horses treated concomitantly with furosemide and clenbuterol were increased, whereas serum concentrations of the drug were decreased. These effects persisted during the study period and varied among horses.
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M3 - Article
C2 - 12447840
AN - SCOPUS:79251498957
VL - 3
JO - Veterinary therapeutics : research in applied veterinary medicine
JF - Veterinary therapeutics : research in applied veterinary medicine
SN - 1528-3593
IS - 3
ER -