Comparison of sampling methods for profiling cervicovaginal microbiome in rhesus macaques

Brian A. Schmidt, Ronald Phillips, Matthew Rolston, Reben Raeman, Smita Iyer

Research output: Contribution to journal › Article

1 Citation (Scopus)

Abstract

Cervicovaginal bacteria cause inflammation which in turn increases HIV risk. Profiling the cervicovaginal microbiome, therefore, is instrumental for vaccine development. We show that the microbiome profile captured by cervicovaginal lavage is comparable to samples obtained by vaginal swabs. Thus, lavage may serve as a sampling strategy in NHP vaccine studies.

Original languageEnglish (US)
JournalJournal of Medical Primatology
DOIs
StateAccepted/In press - Jan 1 2018

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Therapeutic Irrigation
Microbiota
Macaca mulatta
Vaccines
vaccine development
inflammation
HIV
vaccines
Inflammation
Bacteria
sampling
bacteria
methodology
microbiome

Keywords

  • 16S rRNA
  • HIV
  • lavage
  • swab

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Comparison of sampling methods for profiling cervicovaginal microbiome in rhesus macaques. / Schmidt, Brian A.; Phillips, Ronald; Rolston, Matthew; Raeman, Reben; Iyer, Smita.

In: Journal of Medical Primatology, 01.01.2018.

Research output: Contribution to journal › Article

Schmidt, BA, Phillips, R, Rolston, M, Raeman, R & Iyer, S 2018, 'Comparison of sampling methods for profiling cervicovaginal microbiome in rhesus macaques', Journal of Medical Primatology. https://doi.org/10.1111/jmp.12381
Schmidt BA, Phillips R, Rolston M, Raeman R, Iyer S. Comparison of sampling methods for profiling cervicovaginal microbiome in rhesus macaques. Journal of Medical Primatology. 2018 Jan 1. https://doi.org/10.1111/jmp.12381
Schmidt, Brian A. ; Phillips, Ronald ; Rolston, Matthew ; Raeman, Reben ; Iyer, Smita. / Comparison of sampling methods for profiling cervicovaginal microbiome in rhesus macaques. In: Journal of Medical Primatology. 2018.
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