Comparison of rat hepatic cholesterol biosynthesis during skim milk versus whey permeate ingestion.

N. L. Keim, J. A. Marlett, C. H. Amundson, L. D. Hagemann

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10 Scopus citations


Whey permeate is an ultrafiltrate of whey that is devoid of protein but contains lactose, salts, and other soluble low molecular weight compounds. These experiments compared cholesterol concentrations of blood plasma, hepatic lipids, and hepatic cholesterol biosynthesis of rats ingesting skim milk powder versus whey permeate powder. Groups of young male rats weighing 90 to 92 g were fed a casein-based diet into which skim milk powder or whey permeate powder was incorporated isocalorically. No effects of skim milk or whey permeate on plasma cholesterol concentrations were observed at any time during 5-wk of feeding. However, 3-hydroxy-3-methylglutaryl co-enzyme A reductase activity was increased by either skim milk or whey permeate feeding. Hepatic cholesterol, triglyceride, and phospholipid concentrations at wk 5 were unchanged. Plasma and hepatic cholesterol responses of rats to whey permeate ingestion are similar to those that occur with skim milk consumption, and plasma and hepatic cholesterol concentrations do not reflect necessarily an increase in hepatic cholesterol biosynthesis.

Original languageEnglish (US)
Pages (from-to)2274-2280
Number of pages7
JournalJournal of Dairy Science
Issue number12
StatePublished - Dec 1982
Externally publishedYes

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • veterinary(all)


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