Comparison of postoperative effects between lidocaine infusion, meloxicam, and their combination in dogs undergoing ovariohysterectomy

Teng Yu Tsai, Shao Kuang Chang, Po-Yen Chou, Lih Seng Yeh

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: To compare the postoperative analgesic effects of intravenous (IV) lidocaine, meloxicam, and their combination in dogs undergoing ovariohysterectomy. Study design: Prospective, randomized, double-blind, controlled clinical trial. Animals: Twenty-seven dogs aged (mean ± SD) 16.1 ± 7.5 months and weighing 22.4 ± 17.9 kg scheduled for ovariohysterectomy. Methods: Anaesthesia was induced with propofol and maintained with isoflurane. Dogs (n = 9 in each group) were allocated to receive just prior to and during surgery one of the following regimens: M group, 0.2 mg kg-1 IV meloxicam then a continuous rate infusion (CRI) of lactated Ringer's at 10 mL kg-1 hour-1; L group, a bolus of lidocaine (1 mg kg-1 IV) then a CRI of lidocaine at 0.025 mg kg-1 minute-1; and M + L group, both the above meloxicam and lidocaine treatments. Pain and sedation were scored, and venous samples taken for serum cortisol and glucose measurement before and at intervals for 12 hours after anaesthesia. Pain scores were assessed using a multi-parameter subjective scoring scale (cumulative scale 0-21) by three observers. The protocol stated that dogs with a total score exceeding 9 or a sub-score above 3 in any one category would receive rescue analgesia. Sedation was scored on a scale of 0-4. Results: There were no significant differences in subjective pain scores, serum cortisol, and glucose concentrations between the three groups. The highest pain score at any time was 5, and no dog required rescue analgesia. None of the three regimens caused any observable side effects during or after anaesthesia. At 1 and 2 hours after extubation dogs in group L were significantly more sedated than in the other two groups. Conclusions and Clinical relevance: This study suggests that, with the scoring system used, IV lidocaine and meloxicam provide similar and adequate post-operative analgesia in healthy dogs undergoing ovariohysterectomy.

Original languageEnglish (US)
Pages (from-to)615-622
Number of pages8
JournalVeterinary Anaesthesia and Analgesia
Volume40
Issue number6
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

meloxicam
lidocaine
spaying
Lidocaine
Dogs
dogs
pain
analgesia
Analgesia
Pain
anesthesia
Anesthesia
sedation
cortisol
Hydrocortisone
Glucose
glucose
analgesic effect
Isoflurane
isoflurane

Keywords

  • Analgesia
  • Dog
  • Lidocaine
  • Meloxicam
  • Ovariohysterectomy

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparison of postoperative effects between lidocaine infusion, meloxicam, and their combination in dogs undergoing ovariohysterectomy. / Tsai, Teng Yu; Chang, Shao Kuang; Chou, Po-Yen; Yeh, Lih Seng.

In: Veterinary Anaesthesia and Analgesia, Vol. 40, No. 6, 01.01.2013, p. 615-622.

Research output: Contribution to journalArticle

@article{5182f3c9f7a04bd6baf60a986235d56a,
title = "Comparison of postoperative effects between lidocaine infusion, meloxicam, and their combination in dogs undergoing ovariohysterectomy",
abstract = "Objective: To compare the postoperative analgesic effects of intravenous (IV) lidocaine, meloxicam, and their combination in dogs undergoing ovariohysterectomy. Study design: Prospective, randomized, double-blind, controlled clinical trial. Animals: Twenty-seven dogs aged (mean ± SD) 16.1 ± 7.5 months and weighing 22.4 ± 17.9 kg scheduled for ovariohysterectomy. Methods: Anaesthesia was induced with propofol and maintained with isoflurane. Dogs (n = 9 in each group) were allocated to receive just prior to and during surgery one of the following regimens: M group, 0.2 mg kg-1 IV meloxicam then a continuous rate infusion (CRI) of lactated Ringer's at 10 mL kg-1 hour-1; L group, a bolus of lidocaine (1 mg kg-1 IV) then a CRI of lidocaine at 0.025 mg kg-1 minute-1; and M + L group, both the above meloxicam and lidocaine treatments. Pain and sedation were scored, and venous samples taken for serum cortisol and glucose measurement before and at intervals for 12 hours after anaesthesia. Pain scores were assessed using a multi-parameter subjective scoring scale (cumulative scale 0-21) by three observers. The protocol stated that dogs with a total score exceeding 9 or a sub-score above 3 in any one category would receive rescue analgesia. Sedation was scored on a scale of 0-4. Results: There were no significant differences in subjective pain scores, serum cortisol, and glucose concentrations between the three groups. The highest pain score at any time was 5, and no dog required rescue analgesia. None of the three regimens caused any observable side effects during or after anaesthesia. At 1 and 2 hours after extubation dogs in group L were significantly more sedated than in the other two groups. Conclusions and Clinical relevance: This study suggests that, with the scoring system used, IV lidocaine and meloxicam provide similar and adequate post-operative analgesia in healthy dogs undergoing ovariohysterectomy.",
keywords = "Analgesia, Dog, Lidocaine, Meloxicam, Ovariohysterectomy",
author = "Tsai, {Teng Yu} and Chang, {Shao Kuang} and Po-Yen Chou and Yeh, {Lih Seng}",
year = "2013",
month = "1",
day = "1",
doi = "10.1111/vaa.12064",
language = "English (US)",
volume = "40",
pages = "615--622",
journal = "Veterinary Anaesthesia and Analgesia",
issn = "1467-2987",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Comparison of postoperative effects between lidocaine infusion, meloxicam, and their combination in dogs undergoing ovariohysterectomy

AU - Tsai, Teng Yu

AU - Chang, Shao Kuang

AU - Chou, Po-Yen

AU - Yeh, Lih Seng

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Objective: To compare the postoperative analgesic effects of intravenous (IV) lidocaine, meloxicam, and their combination in dogs undergoing ovariohysterectomy. Study design: Prospective, randomized, double-blind, controlled clinical trial. Animals: Twenty-seven dogs aged (mean ± SD) 16.1 ± 7.5 months and weighing 22.4 ± 17.9 kg scheduled for ovariohysterectomy. Methods: Anaesthesia was induced with propofol and maintained with isoflurane. Dogs (n = 9 in each group) were allocated to receive just prior to and during surgery one of the following regimens: M group, 0.2 mg kg-1 IV meloxicam then a continuous rate infusion (CRI) of lactated Ringer's at 10 mL kg-1 hour-1; L group, a bolus of lidocaine (1 mg kg-1 IV) then a CRI of lidocaine at 0.025 mg kg-1 minute-1; and M + L group, both the above meloxicam and lidocaine treatments. Pain and sedation were scored, and venous samples taken for serum cortisol and glucose measurement before and at intervals for 12 hours after anaesthesia. Pain scores were assessed using a multi-parameter subjective scoring scale (cumulative scale 0-21) by three observers. The protocol stated that dogs with a total score exceeding 9 or a sub-score above 3 in any one category would receive rescue analgesia. Sedation was scored on a scale of 0-4. Results: There were no significant differences in subjective pain scores, serum cortisol, and glucose concentrations between the three groups. The highest pain score at any time was 5, and no dog required rescue analgesia. None of the three regimens caused any observable side effects during or after anaesthesia. At 1 and 2 hours after extubation dogs in group L were significantly more sedated than in the other two groups. Conclusions and Clinical relevance: This study suggests that, with the scoring system used, IV lidocaine and meloxicam provide similar and adequate post-operative analgesia in healthy dogs undergoing ovariohysterectomy.

AB - Objective: To compare the postoperative analgesic effects of intravenous (IV) lidocaine, meloxicam, and their combination in dogs undergoing ovariohysterectomy. Study design: Prospective, randomized, double-blind, controlled clinical trial. Animals: Twenty-seven dogs aged (mean ± SD) 16.1 ± 7.5 months and weighing 22.4 ± 17.9 kg scheduled for ovariohysterectomy. Methods: Anaesthesia was induced with propofol and maintained with isoflurane. Dogs (n = 9 in each group) were allocated to receive just prior to and during surgery one of the following regimens: M group, 0.2 mg kg-1 IV meloxicam then a continuous rate infusion (CRI) of lactated Ringer's at 10 mL kg-1 hour-1; L group, a bolus of lidocaine (1 mg kg-1 IV) then a CRI of lidocaine at 0.025 mg kg-1 minute-1; and M + L group, both the above meloxicam and lidocaine treatments. Pain and sedation were scored, and venous samples taken for serum cortisol and glucose measurement before and at intervals for 12 hours after anaesthesia. Pain scores were assessed using a multi-parameter subjective scoring scale (cumulative scale 0-21) by three observers. The protocol stated that dogs with a total score exceeding 9 or a sub-score above 3 in any one category would receive rescue analgesia. Sedation was scored on a scale of 0-4. Results: There were no significant differences in subjective pain scores, serum cortisol, and glucose concentrations between the three groups. The highest pain score at any time was 5, and no dog required rescue analgesia. None of the three regimens caused any observable side effects during or after anaesthesia. At 1 and 2 hours after extubation dogs in group L were significantly more sedated than in the other two groups. Conclusions and Clinical relevance: This study suggests that, with the scoring system used, IV lidocaine and meloxicam provide similar and adequate post-operative analgesia in healthy dogs undergoing ovariohysterectomy.

KW - Analgesia

KW - Dog

KW - Lidocaine

KW - Meloxicam

KW - Ovariohysterectomy

UR - http://www.scopus.com/inward/record.url?scp=84885833168&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885833168&partnerID=8YFLogxK

U2 - 10.1111/vaa.12064

DO - 10.1111/vaa.12064

M3 - Article

C2 - 23837712

AN - SCOPUS:84885833168

VL - 40

SP - 615

EP - 622

JO - Veterinary Anaesthesia and Analgesia

JF - Veterinary Anaesthesia and Analgesia

SN - 1467-2987

IS - 6

ER -