Comparison of organochlorine compound concentrations in colostrum and mature milk

Zhiwei Yu, Lubica Palkovicova, Beata Drobna, Jan Petrik, Anton Kocan, Tomas Trnovec, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Human breast milk represents the best choice for the nutrition of infants. It is often used for monitoring human exposures to environmental chemicals. Uniquely suited to meet human biological needs, breast milk composition, especially fat content, changes significantly with time from delivery. With the aim to compare the concentration of organochlorine compounds (OCs) in colostrum versus mature milk, we obtained samples of fourth-fifth day postpartum milk (colostrum) and day-14 postpartum milk (mature milk) from 12 women enrolled in the project "Early Childhood Development and PCB Exposure in Slovakia". The concentrations of selected organochlorine pesticides and congeners of polychlorinated biphenyls (PCBs) were measured using gas chromatography with electron capture detection and reported on lipid adjusted basis. No significant differences were found between organochlorine levels in colostrum and those in mature milk samples. A very close correlation was found between the concentrations of organochlorine compounds in colostrum and mature milk (Spearman correlation coefficient r = 0.94-0.98 for PCBs, and r = 0.85-0.99 for organochlorine pesticides, p < 0.001 for all compounds). The present study concludes that the use of colostrum samples provides a close estimate of the child's exposure to OCs in the early neonatal period and demonstrates that, despite the lower fat content, colostrum specimens are adequate to conduct OC analyses.

Original languageEnglish (US)
Pages (from-to)1012-1018
Number of pages7
JournalChemosphere
Volume66
Issue number6
DOIs
StatePublished - Jan 2007

Fingerprint

Chlorinated Hydrocarbons
Colostrum
milk
Milk
Polychlorinated Biphenyls
Human Milk
Polychlorinated biphenyls
PCB
Pesticides
Oils and fats
Postpartum Period
fat
Fats
Slovakia
Environmental Exposure
Nutrition
organochlorine
Gas chromatography
Gas Chromatography
Lipids

Keywords

  • Breast milk
  • Colostrum
  • Mature milk
  • Milk sampling
  • Organochlorine compounds
  • Postnatal exposure

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Comparison of organochlorine compound concentrations in colostrum and mature milk. / Yu, Zhiwei; Palkovicova, Lubica; Drobna, Beata; Petrik, Jan; Kocan, Anton; Trnovec, Tomas; Hertz-Picciotto, Irva.

In: Chemosphere, Vol. 66, No. 6, 01.2007, p. 1012-1018.

Research output: Contribution to journalArticle

Yu, Z, Palkovicova, L, Drobna, B, Petrik, J, Kocan, A, Trnovec, T & Hertz-Picciotto, I 2007, 'Comparison of organochlorine compound concentrations in colostrum and mature milk', Chemosphere, vol. 66, no. 6, pp. 1012-1018. https://doi.org/10.1016/j.chemosphere.2006.07.043
Yu Z, Palkovicova L, Drobna B, Petrik J, Kocan A, Trnovec T et al. Comparison of organochlorine compound concentrations in colostrum and mature milk. Chemosphere. 2007 Jan;66(6):1012-1018. https://doi.org/10.1016/j.chemosphere.2006.07.043
Yu, Zhiwei ; Palkovicova, Lubica ; Drobna, Beata ; Petrik, Jan ; Kocan, Anton ; Trnovec, Tomas ; Hertz-Picciotto, Irva. / Comparison of organochlorine compound concentrations in colostrum and mature milk. In: Chemosphere. 2007 ; Vol. 66, No. 6. pp. 1012-1018.
@article{22b2dafa82614224b3e6a2ee0a56c66a,
title = "Comparison of organochlorine compound concentrations in colostrum and mature milk",
abstract = "Human breast milk represents the best choice for the nutrition of infants. It is often used for monitoring human exposures to environmental chemicals. Uniquely suited to meet human biological needs, breast milk composition, especially fat content, changes significantly with time from delivery. With the aim to compare the concentration of organochlorine compounds (OCs) in colostrum versus mature milk, we obtained samples of fourth-fifth day postpartum milk (colostrum) and day-14 postpartum milk (mature milk) from 12 women enrolled in the project {"}Early Childhood Development and PCB Exposure in Slovakia{"}. The concentrations of selected organochlorine pesticides and congeners of polychlorinated biphenyls (PCBs) were measured using gas chromatography with electron capture detection and reported on lipid adjusted basis. No significant differences were found between organochlorine levels in colostrum and those in mature milk samples. A very close correlation was found between the concentrations of organochlorine compounds in colostrum and mature milk (Spearman correlation coefficient r = 0.94-0.98 for PCBs, and r = 0.85-0.99 for organochlorine pesticides, p < 0.001 for all compounds). The present study concludes that the use of colostrum samples provides a close estimate of the child's exposure to OCs in the early neonatal period and demonstrates that, despite the lower fat content, colostrum specimens are adequate to conduct OC analyses.",
keywords = "Breast milk, Colostrum, Mature milk, Milk sampling, Organochlorine compounds, Postnatal exposure",
author = "Zhiwei Yu and Lubica Palkovicova and Beata Drobna and Jan Petrik and Anton Kocan and Tomas Trnovec and Irva Hertz-Picciotto",
year = "2007",
month = "1",
doi = "10.1016/j.chemosphere.2006.07.043",
language = "English (US)",
volume = "66",
pages = "1012--1018",
journal = "Chemosphere",
issn = "0045-6535",
publisher = "Elsevier Limited",
number = "6",

}

TY - JOUR

T1 - Comparison of organochlorine compound concentrations in colostrum and mature milk

AU - Yu, Zhiwei

AU - Palkovicova, Lubica

AU - Drobna, Beata

AU - Petrik, Jan

AU - Kocan, Anton

AU - Trnovec, Tomas

AU - Hertz-Picciotto, Irva

PY - 2007/1

Y1 - 2007/1

N2 - Human breast milk represents the best choice for the nutrition of infants. It is often used for monitoring human exposures to environmental chemicals. Uniquely suited to meet human biological needs, breast milk composition, especially fat content, changes significantly with time from delivery. With the aim to compare the concentration of organochlorine compounds (OCs) in colostrum versus mature milk, we obtained samples of fourth-fifth day postpartum milk (colostrum) and day-14 postpartum milk (mature milk) from 12 women enrolled in the project "Early Childhood Development and PCB Exposure in Slovakia". The concentrations of selected organochlorine pesticides and congeners of polychlorinated biphenyls (PCBs) were measured using gas chromatography with electron capture detection and reported on lipid adjusted basis. No significant differences were found between organochlorine levels in colostrum and those in mature milk samples. A very close correlation was found between the concentrations of organochlorine compounds in colostrum and mature milk (Spearman correlation coefficient r = 0.94-0.98 for PCBs, and r = 0.85-0.99 for organochlorine pesticides, p < 0.001 for all compounds). The present study concludes that the use of colostrum samples provides a close estimate of the child's exposure to OCs in the early neonatal period and demonstrates that, despite the lower fat content, colostrum specimens are adequate to conduct OC analyses.

AB - Human breast milk represents the best choice for the nutrition of infants. It is often used for monitoring human exposures to environmental chemicals. Uniquely suited to meet human biological needs, breast milk composition, especially fat content, changes significantly with time from delivery. With the aim to compare the concentration of organochlorine compounds (OCs) in colostrum versus mature milk, we obtained samples of fourth-fifth day postpartum milk (colostrum) and day-14 postpartum milk (mature milk) from 12 women enrolled in the project "Early Childhood Development and PCB Exposure in Slovakia". The concentrations of selected organochlorine pesticides and congeners of polychlorinated biphenyls (PCBs) were measured using gas chromatography with electron capture detection and reported on lipid adjusted basis. No significant differences were found between organochlorine levels in colostrum and those in mature milk samples. A very close correlation was found between the concentrations of organochlorine compounds in colostrum and mature milk (Spearman correlation coefficient r = 0.94-0.98 for PCBs, and r = 0.85-0.99 for organochlorine pesticides, p < 0.001 for all compounds). The present study concludes that the use of colostrum samples provides a close estimate of the child's exposure to OCs in the early neonatal period and demonstrates that, despite the lower fat content, colostrum specimens are adequate to conduct OC analyses.

KW - Breast milk

KW - Colostrum

KW - Mature milk

KW - Milk sampling

KW - Organochlorine compounds

KW - Postnatal exposure

UR - http://www.scopus.com/inward/record.url?scp=33751255413&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33751255413&partnerID=8YFLogxK

U2 - 10.1016/j.chemosphere.2006.07.043

DO - 10.1016/j.chemosphere.2006.07.043

M3 - Article

VL - 66

SP - 1012

EP - 1018

JO - Chemosphere

JF - Chemosphere

SN - 0045-6535

IS - 6

ER -