Comparison of oncophilic radiopharmaceuticals, *I‐fibrinogen, 67Ga‐ citrate, 111In‐bleomycin, and *I‐bleomycin in tumor‐bearing mice

Gerald L. Denardo, Kenneth A. Krohn, Sally J. Denardo

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The pharmacokinetics of 67Ga‐citrate, 111‐bleomycin, *I‐bleomycin, and *I‐fibrinogen were compared in a murine KHJJ tumor model in order to assess their relative potential as agents for in vivo detection of cancer. Although all four agents have been reported to be clinically efficacious, in this tumor model, *I‐fibrinogen and 67Ga‐citrate had the greatest tumor accumulation with maximum concentrations of 11.7% and 10.5% respectively. However, both these radiopharmaceuticals cleared slowly from the blood and animal. The maximum tumor concentrations of 111In‐bleomycin and *I‐bleomycin were 2.9% and 2.6% respectively, but *I‐bleomycin had the advantage of rapid clearance from the blood and animal. 67Ga‐citrate did not achieve its maximum tumor concentration until 24 hours after administration, whereas the other radiopharmaceuticals achieved maximum tumor concentration within several hours of administration. From these observations 123I‐bleomycin seems to deserve clinical trials in patients. 123I‐fibrinogen appears to have significant oncophilic potential if its clearance from the animal can be accelerated without altering its accumulation in the tumor. Cancer 40:2923‐2929, 1977.

Original languageEnglish (US)
Pages (from-to)2923-2929
Number of pages7
JournalCancer
Volume40
Issue number6
DOIs
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology
  • Cancer Research

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