Comparison of myocardial contrast enhancement via cardiac magnetic resonance imaging in healthy cats and cats with hypertrophic cardiomyopathy

Kristin A. MacDonald, Erik R Wisner, Richard F. Larson, Tyler Klose, Philip H Kass, Mark D Kittleson

Research output: Contribution to journalArticle

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Abstract

Objective - To quantify myocardial contrast enhancement (MCE) of the left ventricle (LV) by use of cardiac magnetic resonance imaging (CMRI) in healthy cats and cats with hypertrophic cardiomyopathy (HCM) and to compare MCE between the 2 groups. Animals - 10 healthy cats and 26 Maine Coon cats with moderate to severe HCM but without clinical evidence of congestive heart failure. Procedure - Anesthetized cats underwent gradient echo CMRI examination. Short-axis images of the LV were acquired before and 7 minutes after IV administration of gadolinium dimeglumine. Regions of interest were manually traced in the quadrants of 5 mid-LV slices acquired at end systole, and the MCE percentage was calculated from summed weight-averaged data from all slices. Doppler tissue imaging echocardiography was performed to measure the early diastolic myocardial velocity (Em) as an index of diastolic function. Three-way repeated-measures ANOVA was used to determine differences in MCE between cats with HCM and healthy cats. Simple linear regression was used to assess whether MCE was correlated with LV mass, LV mass index (LVMI), or Em. A Student t test was used to compare the SDs of the postcontrast myocardial signal intensity between the 2 groups. Results - There was no difference in MCE between cats with HCM and healthy cats. There was no correlation of MCE with LV mass, LVMI, or Em. There was no difference in heterogeneity of signal intensities of LV myocardium between the 2 groups. Conclusions and clinical relevance - Contrast-enhancement CMRI was not useful in detecting diffuse myocardial fibrosis in cats with HCM.

Original languageEnglish (US)
Pages (from-to)1891-1894
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume66
Issue number11
DOIs
StatePublished - Nov 2005

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Hypertrophic Cardiomyopathy
cardiomyopathy
magnetic resonance imaging
Cats
Magnetic Resonance Imaging
cats
Heart Ventricles
gadolinium
Systole
echocardiography
Gadolinium
heart failure
myocardium
fibrosis
intravenous injection
Echocardiography
Linear Models
Myocardium
Analysis of Variance
Fibrosis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Comparison of myocardial contrast enhancement via cardiac magnetic resonance imaging in healthy cats and cats with hypertrophic cardiomyopathy. / MacDonald, Kristin A.; Wisner, Erik R; Larson, Richard F.; Klose, Tyler; Kass, Philip H; Kittleson, Mark D.

In: American Journal of Veterinary Research, Vol. 66, No. 11, 11.2005, p. 1891-1894.

Research output: Contribution to journalArticle

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N2 - Objective - To quantify myocardial contrast enhancement (MCE) of the left ventricle (LV) by use of cardiac magnetic resonance imaging (CMRI) in healthy cats and cats with hypertrophic cardiomyopathy (HCM) and to compare MCE between the 2 groups. Animals - 10 healthy cats and 26 Maine Coon cats with moderate to severe HCM but without clinical evidence of congestive heart failure. Procedure - Anesthetized cats underwent gradient echo CMRI examination. Short-axis images of the LV were acquired before and 7 minutes after IV administration of gadolinium dimeglumine. Regions of interest were manually traced in the quadrants of 5 mid-LV slices acquired at end systole, and the MCE percentage was calculated from summed weight-averaged data from all slices. Doppler tissue imaging echocardiography was performed to measure the early diastolic myocardial velocity (Em) as an index of diastolic function. Three-way repeated-measures ANOVA was used to determine differences in MCE between cats with HCM and healthy cats. Simple linear regression was used to assess whether MCE was correlated with LV mass, LV mass index (LVMI), or Em. A Student t test was used to compare the SDs of the postcontrast myocardial signal intensity between the 2 groups. Results - There was no difference in MCE between cats with HCM and healthy cats. There was no correlation of MCE with LV mass, LVMI, or Em. There was no difference in heterogeneity of signal intensities of LV myocardium between the 2 groups. Conclusions and clinical relevance - Contrast-enhancement CMRI was not useful in detecting diffuse myocardial fibrosis in cats with HCM.

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