Comparison of Manual and Automated Measurements of Tracheobronchial Airway Geometry in Three Balb/c Mice

Asef Islam, Michael J. Oldham, Anthony S. Wexler

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Mammalian lungs are comprised of large numbers of tracheobronchial airways that transition from the trachea to alveoli. Studies as wide ranging as pollutant deposition and lung development rely on accurate characterization of these airways. Advancements in CT imaging and the value of computational approaches in eliminating the burden of manual measurement are providing increased efficiency in obtaining this geometric data. In this study, we compare an automated method to a manual one for the first six generations of three Balb/c mouse lungs. We find good agreement between manual and automated methods and that much of the disagreement can be attributed to method precision. Using the automated method, we then provide anatomical data for the entire tracheobronchial airway tree from three Balb/C mice.

Original languageEnglish (US)
JournalAnatomical Record
DOIs
StateAccepted/In press - 2017

Keywords

  • Airway geometry
  • Automated measurement
  • BALB/c mice
  • CT imaging

ASJC Scopus subject areas

  • Anatomy
  • Biotechnology
  • Histology
  • Ecology, Evolution, Behavior and Systematics

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