Comparison of intensity-modulated radiotherapy using helical tomotherapy and segmental multileaf collimator-based techniques for nasopharyngeal carcinoma: Dosimetric analysis incorporating quality assurance guidelines from RTOG 0225

Allen M. Chen, Nancy Y. Lee, Claus C. Yang, Tianxiao Liu, Samir Narayan, Srinivasan Vijayakumar, James A. Purdy

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Intensity-modulated radiotherapy (IMRT) treatment plans generated by segmental multileaf collimator (SMLC) and helical tomotherapy (HT) techniques for patients with nasopharyngeal carcinoma were compared using standardized criteria proposed by Radiation Therapy Oncology Group (RTOG) protocol 0225. The goal was to deliver a prescribed dose of 70 Gy to at least 95% of the planning target volume (PTV) encompassing gross tumor, and 59.4 Gy and 50.4 Gy, respectively, to areas at high and low risk for microscopic disease, over 33 treatments while respecting constraints to organs at risk (OAR). HT-IMRT significantly reduced dose to the contralateral parotid gland and improved dose homogeneity to the PTVs. Mean doses to the inner and middle ears were also reduced by 18% and 24%, respectively, on the ipsilateral side, and 24%, and 35%, respectively, on the contralateral side using HT-IMRT compared to SMLC-IMRT. Additionally, HT-IMRT reduced mean doses to brainstem (p = 0.02), larynx (p = 0.03), and oral cavity (p = 0.03). These findings suggest that HT-IMRT may be of improve the therapeutic ratio in the radiotherapeutic treatment of nasopharyngeal carcinoma.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalTechnology in Cancer Research and Treatment
Volume9
Issue number3
StatePublished - Jun 2010

Fingerprint

Intensity-Modulated Radiotherapy
Radiation Oncology
Radiotherapy
Guidelines
Nasopharyngeal carcinoma
Organs at Risk
Parotid Gland
Middle Ear
Inner Ear
Therapeutics
Larynx
Brain Stem
Mouth

Keywords

  • Head and neck cancer
  • Intensity-modulated radiotherapy
  • Nasopharyngeal carcinoma
  • Tomotherapy
  • Treatment planning

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Comparison of intensity-modulated radiotherapy using helical tomotherapy and segmental multileaf collimator-based techniques for nasopharyngeal carcinoma : Dosimetric analysis incorporating quality assurance guidelines from RTOG 0225. / Chen, Allen M.; Lee, Nancy Y.; Yang, Claus C.; Liu, Tianxiao; Narayan, Samir; Vijayakumar, Srinivasan; Purdy, James A.

In: Technology in Cancer Research and Treatment, Vol. 9, No. 3, 06.2010, p. 291-298.

Research output: Contribution to journalArticle

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abstract = "Intensity-modulated radiotherapy (IMRT) treatment plans generated by segmental multileaf collimator (SMLC) and helical tomotherapy (HT) techniques for patients with nasopharyngeal carcinoma were compared using standardized criteria proposed by Radiation Therapy Oncology Group (RTOG) protocol 0225. The goal was to deliver a prescribed dose of 70 Gy to at least 95{\%} of the planning target volume (PTV) encompassing gross tumor, and 59.4 Gy and 50.4 Gy, respectively, to areas at high and low risk for microscopic disease, over 33 treatments while respecting constraints to organs at risk (OAR). HT-IMRT significantly reduced dose to the contralateral parotid gland and improved dose homogeneity to the PTVs. Mean doses to the inner and middle ears were also reduced by 18{\%} and 24{\%}, respectively, on the ipsilateral side, and 24{\%}, and 35{\%}, respectively, on the contralateral side using HT-IMRT compared to SMLC-IMRT. Additionally, HT-IMRT reduced mean doses to brainstem (p = 0.02), larynx (p = 0.03), and oral cavity (p = 0.03). These findings suggest that HT-IMRT may be of improve the therapeutic ratio in the radiotherapeutic treatment of nasopharyngeal carcinoma.",
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