Comparison of immunomodulatory functions of three peptides from the chicken bursa of Fabricius

Xiao Dong Liu, Bin Zhou, Rui Bing Cao, Xiuli Feng, Xin Feng Li, Pu Yan Chen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The bursa of Fabricius (BF) is the acknowledged central humoral immune organ unique to birds which plays important roles in B cell development and antibody production. Little information on immunomodulatory functions of BF is reported, except for several reported active bursal-derived peptides. Three peptides were identified and characterized from BF through RP-HPLC and MADIL-TOF methods. They are named as bursal peptide (BP)-I, BP-II, BP-III. These peptides promoted CFU pre-B formation and decreased PU.1 expression. The different immunomodulatory activities of these three bursal peptides on antibody and cytokine productions were verified by the immunization comparative experiment. The results showed the three bursal peptides enhanced AIV-specific antibody and cytokine production, T-cell immunophenotyping at reachable concentrations. These results indicate the important orientations for the comprehensive understanding of the humoral central immune system, and provide a novel insight on new experimental reagents for immuno-adjuvant or immunopharmacological.

Original languageEnglish (US)
Pages (from-to)57-61
Number of pages5
JournalRegulatory Peptides
Volume186
DOIs
StatePublished - Sep 1 2013
Externally publishedYes

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Keywords

  • Bursal peptide (BP)
  • Immunization experiment
  • Immunomodulatory function
  • Reversed-phase HPLC

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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