TY - GEN
T1 - Comparison of gene identification based on artificial neural network pre-processing with k-means cluster and principal component analysis
AU - Peterson, Leif E.
AU - Coleman, Matthew A
PY - 2006
Y1 - 2006
N2 - A combination of gene ranking, dimensional reduction, and recursive feature elimination (RFE) using a BP-MLP artificial neural network (ANN) was used to select genes for DNA microarray classification. Use of k-means cluster analysis for dimensional reduction and maximum sensitivity for RFE resulted in 64-gene models with fewer invariant and correlated features when compared with PCA and mimimum error. In conclusion, k-means cluster analysis and sensitivity may be better suited for classifying diseases for which gene expression is more strongly influenced by pathway heterogeneity.
AB - A combination of gene ranking, dimensional reduction, and recursive feature elimination (RFE) using a BP-MLP artificial neural network (ANN) was used to select genes for DNA microarray classification. Use of k-means cluster analysis for dimensional reduction and maximum sensitivity for RFE resulted in 64-gene models with fewer invariant and correlated features when compared with PCA and mimimum error. In conclusion, k-means cluster analysis and sensitivity may be better suited for classifying diseases for which gene expression is more strongly influenced by pathway heterogeneity.
UR - http://www.scopus.com/inward/record.url?scp=33745182255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745182255&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33745182255
SN - 3540325298
SN - 9783540325291
VL - 3849 LNAI
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 267
EP - 276
BT - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
T2 - 6th International Workshop - Fuzzy Logic and Applications
Y2 - 15 September 2005 through 17 September 2005
ER -