TY - JOUR
T1 - Comparison of effectiveness of silicone gel sheeting with microporous paper tape in the prevention of hypertrophic scarring in a rabbit model
AU - Tollefson, Travis Tate
AU - Kamangar, Faranak
AU - Aminpour, Shervin
AU - Lee, Andrew
AU - Durbin-Johnson, Blythe
AU - Tinling, Steven
PY - 2012/1
Y1 - 2012/1
N2 - Objective: To determine the effectiveness of treating scars with microporous paper tape or silicone gel sheeting (SGS) in preventing hypertrophic scarring Methods: Forty hypertrophic scars were induced in a validated rabbit ear model. Wounds were randomized and bandaged for 30 days with either SGS (20 wounds), paper tape (20 wounds), or untreated controls (40 wounds). Two outcome measures of hypertrophic scarring included (1) histologic measurement of scar elevation index (SEI) and (2) blinded photograph analysis using a visual analog scale. Results: In histologic comparison, no difference in mean (SE) SEI between treatment groups was seen (paper tape group, 1.32 [0.2]; SGS group, 1.41 [0.18]; control, 1.35 [0.23]; P=.51). In photographic analysis, both treatment groups were superior to the control group (P<.01), whereas no difference was seen between the SGS and paper tape groups (P=.88). Conclusions: Paper tape and SGS demonstrated equal effectiveness in the prevention of hypertrophic scarring on visual analysis, whereas histologic analysis demonstrated no difference in treatment groups from controls. The effectiveness of paper tape in preventing hypertrophic scarring in humans will require further laboratory and clinical investigation.
AB - Objective: To determine the effectiveness of treating scars with microporous paper tape or silicone gel sheeting (SGS) in preventing hypertrophic scarring Methods: Forty hypertrophic scars were induced in a validated rabbit ear model. Wounds were randomized and bandaged for 30 days with either SGS (20 wounds), paper tape (20 wounds), or untreated controls (40 wounds). Two outcome measures of hypertrophic scarring included (1) histologic measurement of scar elevation index (SEI) and (2) blinded photograph analysis using a visual analog scale. Results: In histologic comparison, no difference in mean (SE) SEI between treatment groups was seen (paper tape group, 1.32 [0.2]; SGS group, 1.41 [0.18]; control, 1.35 [0.23]; P=.51). In photographic analysis, both treatment groups were superior to the control group (P<.01), whereas no difference was seen between the SGS and paper tape groups (P=.88). Conclusions: Paper tape and SGS demonstrated equal effectiveness in the prevention of hypertrophic scarring on visual analysis, whereas histologic analysis demonstrated no difference in treatment groups from controls. The effectiveness of paper tape in preventing hypertrophic scarring in humans will require further laboratory and clinical investigation.
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U2 - 10.1001/archfacial.2011.62
DO - 10.1001/archfacial.2011.62
M3 - Article
C2 - 21844480
AN - SCOPUS:84857846533
VL - 14
SP - 45
EP - 51
JO - JAMA Facial Plastic Surgery
JF - JAMA Facial Plastic Surgery
SN - 2168-6076
IS - 1
ER -