Comparison of Doppler, oscillometric, auricular and carotid arterial blood pressure measurements in isoflurane anesthetized New Zealand white rabbits

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Abstract

Objective: To assess agreement between carotid arterial pressure and auricular arterial, thoracic limb Doppler or thoracic limb oscillometric blood pressure measurements. Study design: Prospective experimental study. Animals: Six adult New Zealand white rabbits. Methods: Rabbits were anesthetized with isoflurane in oxygen at 1, 1.5 and 2 MAC on two separate occasions. Catheters in the auricular and the contralateral external carotid artery were connected to calibrated pressure transducers via non-compliant tubing. Inflatable cuffs of width equal to approximately 40% of the limb circumference were placed above the carpus on both thoracic limbs with a Doppler transducer placed distal to the cuff on one. Systolic (SAP) and mean (MAP) arterial blood pressure measurements were obtained at each dose, on each occasion. Agreement between measurement techniques was evaluated by repeated measures Bland Altman analysis with carotid pressure as the reference. Variation in bias over the measurement range was evaluated by regression analysis. Results: Carotid MAP and SAP ranged from 20 to 65 mmHg and 37 to 103 mmHg respectively. Bias and 95% limits of agreement for auricular and oscillometric MAP were 7 (0-14) and -5 (-21-11) mmHg, respectively, and for auricular, oscillometric and Doppler SAP were 23 (8-37), -2 (-24-20) and 13 (-14-39) mmHg, respectively. Bias varied significantly over the measurement range (p < 0.001) for all three SAP techniques but not for MAP measurements. Conclusions and clinical relevance: Limits of agreement for all measurements were large but less so for MAP than SAP. Variation in bias with SAP should be considered when using these measurements clinically.

Original languageEnglish (US)
Pages (from-to)393-397
Number of pages5
JournalVeterinary Anaesthesia and Analgesia
Volume41
Issue number4
DOIs
StatePublished - 2014

Fingerprint

New Zealand White rabbit
Isoflurane
isoflurane
blood pressure
Arterial Pressure
Extremities
Rabbits
Thorax
limbs (animal)
chest
Pressure Transducers
External Carotid Artery
transducers (equipment)
Transducers
Research Design
Catheters
Regression Analysis
Prospective Studies
Oxygen
Blood Pressure

Keywords

  • Arterial pressure
  • Blood pressure measurement
  • Isoflurane
  • Rabbit

ASJC Scopus subject areas

  • veterinary(all)
  • Medicine(all)

Cite this

@article{14e8580a5adf4160a5ef77817116424d,
title = "Comparison of Doppler, oscillometric, auricular and carotid arterial blood pressure measurements in isoflurane anesthetized New Zealand white rabbits",
abstract = "Objective: To assess agreement between carotid arterial pressure and auricular arterial, thoracic limb Doppler or thoracic limb oscillometric blood pressure measurements. Study design: Prospective experimental study. Animals: Six adult New Zealand white rabbits. Methods: Rabbits were anesthetized with isoflurane in oxygen at 1, 1.5 and 2 MAC on two separate occasions. Catheters in the auricular and the contralateral external carotid artery were connected to calibrated pressure transducers via non-compliant tubing. Inflatable cuffs of width equal to approximately 40{\%} of the limb circumference were placed above the carpus on both thoracic limbs with a Doppler transducer placed distal to the cuff on one. Systolic (SAP) and mean (MAP) arterial blood pressure measurements were obtained at each dose, on each occasion. Agreement between measurement techniques was evaluated by repeated measures Bland Altman analysis with carotid pressure as the reference. Variation in bias over the measurement range was evaluated by regression analysis. Results: Carotid MAP and SAP ranged from 20 to 65 mmHg and 37 to 103 mmHg respectively. Bias and 95{\%} limits of agreement for auricular and oscillometric MAP were 7 (0-14) and -5 (-21-11) mmHg, respectively, and for auricular, oscillometric and Doppler SAP were 23 (8-37), -2 (-24-20) and 13 (-14-39) mmHg, respectively. Bias varied significantly over the measurement range (p < 0.001) for all three SAP techniques but not for MAP measurements. Conclusions and clinical relevance: Limits of agreement for all measurements were large but less so for MAP than SAP. Variation in bias with SAP should be considered when using these measurements clinically.",
keywords = "Arterial pressure, Blood pressure measurement, Isoflurane, Rabbit",
author = "Barter, {Linda S} and Epstein, {Steven E}",
year = "2014",
doi = "10.1111/vaa.12131",
language = "English (US)",
volume = "41",
pages = "393--397",
journal = "Veterinary Anaesthesia and Analgesia",
issn = "1467-2987",
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T1 - Comparison of Doppler, oscillometric, auricular and carotid arterial blood pressure measurements in isoflurane anesthetized New Zealand white rabbits

AU - Barter, Linda S

AU - Epstein, Steven E

PY - 2014

Y1 - 2014

N2 - Objective: To assess agreement between carotid arterial pressure and auricular arterial, thoracic limb Doppler or thoracic limb oscillometric blood pressure measurements. Study design: Prospective experimental study. Animals: Six adult New Zealand white rabbits. Methods: Rabbits were anesthetized with isoflurane in oxygen at 1, 1.5 and 2 MAC on two separate occasions. Catheters in the auricular and the contralateral external carotid artery were connected to calibrated pressure transducers via non-compliant tubing. Inflatable cuffs of width equal to approximately 40% of the limb circumference were placed above the carpus on both thoracic limbs with a Doppler transducer placed distal to the cuff on one. Systolic (SAP) and mean (MAP) arterial blood pressure measurements were obtained at each dose, on each occasion. Agreement between measurement techniques was evaluated by repeated measures Bland Altman analysis with carotid pressure as the reference. Variation in bias over the measurement range was evaluated by regression analysis. Results: Carotid MAP and SAP ranged from 20 to 65 mmHg and 37 to 103 mmHg respectively. Bias and 95% limits of agreement for auricular and oscillometric MAP were 7 (0-14) and -5 (-21-11) mmHg, respectively, and for auricular, oscillometric and Doppler SAP were 23 (8-37), -2 (-24-20) and 13 (-14-39) mmHg, respectively. Bias varied significantly over the measurement range (p < 0.001) for all three SAP techniques but not for MAP measurements. Conclusions and clinical relevance: Limits of agreement for all measurements were large but less so for MAP than SAP. Variation in bias with SAP should be considered when using these measurements clinically.

AB - Objective: To assess agreement between carotid arterial pressure and auricular arterial, thoracic limb Doppler or thoracic limb oscillometric blood pressure measurements. Study design: Prospective experimental study. Animals: Six adult New Zealand white rabbits. Methods: Rabbits were anesthetized with isoflurane in oxygen at 1, 1.5 and 2 MAC on two separate occasions. Catheters in the auricular and the contralateral external carotid artery were connected to calibrated pressure transducers via non-compliant tubing. Inflatable cuffs of width equal to approximately 40% of the limb circumference were placed above the carpus on both thoracic limbs with a Doppler transducer placed distal to the cuff on one. Systolic (SAP) and mean (MAP) arterial blood pressure measurements were obtained at each dose, on each occasion. Agreement between measurement techniques was evaluated by repeated measures Bland Altman analysis with carotid pressure as the reference. Variation in bias over the measurement range was evaluated by regression analysis. Results: Carotid MAP and SAP ranged from 20 to 65 mmHg and 37 to 103 mmHg respectively. Bias and 95% limits of agreement for auricular and oscillometric MAP were 7 (0-14) and -5 (-21-11) mmHg, respectively, and for auricular, oscillometric and Doppler SAP were 23 (8-37), -2 (-24-20) and 13 (-14-39) mmHg, respectively. Bias varied significantly over the measurement range (p < 0.001) for all three SAP techniques but not for MAP measurements. Conclusions and clinical relevance: Limits of agreement for all measurements were large but less so for MAP than SAP. Variation in bias with SAP should be considered when using these measurements clinically.

KW - Arterial pressure

KW - Blood pressure measurement

KW - Isoflurane

KW - Rabbit

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