Comparison of Coronary Thermodilution and Doppler Velocity for Assessing Coronary Flow Reserve

William F. Fearon, H. M Omar Farouque, Leora B. Balsam, David T Cooke, Robert C. Robbins, Peter J. Fitzgerald, Alan C. Yeung, Paul G. Yock

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Background - Thermodilution coronary flow reserve (CFRthermo) is a new technique for invasively measuring coronary flow reserve (CFR) with a coronary pressure wire and is based on the ability of the pressure transducer to also measure temperature changes. Whether CFRthermo correlates well enough with absolute flow-derived CFR (CFRflow) to replace Doppler wire-derived CFR (CFRDoppler) remains unclear. Methods and Results - In an open-chest pig model, CFRthermo was measured in the left anterior descending (LAD) artery and compared with CFRDoppler and CFR flow, measured with an external flow probe placed around the LAD. In 9 pigs, CFR was measured simultaneously by all 3 means in the normal LAD and after creation of an epicardial LAD stenosis. To determine the added effect of microvascular disease, measurements of flow reserve were also performed after disruption of the coronary microcirculation with embolized microspheres. Intracoronary papaverine (20 mg) was used to induce hyperemia. In a total of 61 paired measurements, CFRthermo correlated strongly with the reference standard CFRflow (r=0.85, P<0.001). CFR Doppler correlated less well with CFRflow (r=0.72, P<0.001). Bland-Altman analysis showed a closer agreement between CFR thermo and CFRflow. Conclusion - CFRthermo correlates better with CFRflow than does CFRDoppler.

Original languageEnglish (US)
Pages (from-to)2198-2200
Number of pages3
Issue number18
StatePublished - Nov 4 2003
Externally publishedYes


  • Blood flow
  • Coronary disease
  • Microcirculation
  • Pressure

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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