Comparison of core needle biopsy and fine-needle aspiration of enlarged peripheral lymph nodes for antemortem diagnosis of enzootic bovine lymphosarcoma in cattle

Kevin E. Washburn, Robert N. Streeter, Terry W Lehenbauer, Timothy A. Snider, Grant B. Rezabek, Jerry W. Ritchey, James H. Meinkoth, Robin W. Allison, Theresa E. Rizzi, Melanie J. Boileau

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Objective - To determine whether antemortem core needle biopsy and fine-needle aspiration of enlarged peripheral lymph nodes could be used to distinguish between inflammation and lymphosarcoma in cattle. Design-Prospective study. Animals - 25 cattle with enlarged peripheral lymph nodes. Procedures - Antemortem biopsies of the selected lymph nodes were performed with an 18-gauge, 12-cm core needle biopsy instrument. Fine-needle aspirates were performed with a 20-gauge, 4-cm needle. Specimens were analyzed by pathologists who were unaware of clinical findings and final necropsy findings, and specimens were categorized as reactive, neoplastic, or nondiagnostic for comparison with necropsy results. Results - Sensitivity and specificity of core needle biopsy ranged from 38% to 67% and from 80% to 25%, respectively. Sensitivity of fine-needle aspiration ranged from 41% to 53%, and specificity was 100%. Predictive values for positive test results ranged from 77% to 89% for core needle biopsy and were 100% for fine-needle aspiration. Predictive values for negative test results were low for both core needle biopsy and fine-needle aspiration. Conclusions and Clinical Relevance - Results indicated that core needle biopsy and fine-needle aspiration can aid in the antemortem diagnosis of bovine enzootic lymphosarcoma. Results of fine-needle aspiration of enlarged peripheral lymph nodes were more specific and more predictive for a positive test result than were results of core needle biopsy.

Original languageEnglish (US)
Pages (from-to)228-232
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume230
Issue number2
DOIs
StatePublished - Jan 15 2007
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)

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