Comparison of contractile state and myosin isozymes of rat right and left ventricular myocardium

W. W. Brooks, O. H L Bing, A. S. Blaustein, P. D. Allen

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We compared myocardial mechanics and myosin isozymes of right and left ventricular papillary muscles from adult (6 to 8 month old) male rats. Analysis of force velocity relations indicate that right ventricular papillary muscles contract more rapidly than left at light loads (2.68±0.13 vs 2.18±0.07 muscle lengths/s measured 75 ms following stimulation, at 0.5 g/mm2; P<0.01). Right ventricular papillary muscles had significantly more of the α heavy chain containing V1 myosin isozyme and less of the V3 containing β heavy chain myosin isozyme than left ventricular preparations (P<0.05). Papillary muscle and ventricular free wall myosin isozyme distribution were not significantly different within their respective chambers. The presence of a relatively larger proportion of the α heavy chain containing myosin isozyme (V1) in right ventricle papillary muscles relative to left correlated with the more rapid velocities of shortening seen in right ventricular papillary muscles (r=0.60; P<0.01).

Original languageEnglish (US)
Pages (from-to)433-440
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume19
Issue number5
DOIs
StatePublished - 1987
Externally publishedYes

Keywords

  • Myocardial mechanics
  • Myosin isozymes
  • Papillary muscle
  • Right and left ventricle

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

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