Comparison of clinical, maternal, and self pubertal assessments: Implications for health studies

Mary Beth Terry, Mandy Goldberg, Sarah Schechter, Lauren C. Houghton, Melissa L. White, Karen O'Toole, Wendy K. Chung, Mary B. Daly, Theresa H Keegan, Irene L. Andrulis, Angela R. Bradbury, Lisa Schwartz, Julia A. Knight, Esther M. John, Saundra S. Buys

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Abstract

BACKGROUND: Most epidemiologic studies of puberty have only 1 source of pubertal development information (maternal, self or clinical). Interpretation of results across studies requires data on reliability and validity across sources. METHODS: The LEGACY Girls Study, a 5-site prospective study of girls aged 6 to 13 years (n = 1040) collected information on breast and pubic hair development from mothers (for all daughters) and daughters (if ≥10 years) according to Tanner stage (T1-5) drawings. At 2 LEGACY sites, girls (n = 282) were also examined in the clinic by trained professionals. We assessed agreement (κ) and validity (sensitivity and specificity) with the clinical assessment (gold standard) for both the mothers' and daughters' assessment in the subcohort of 282. In the entire cohort, we examined the agreement between mothers and daughters. RESULTS: Compared with clinical assessment, sensitivity of maternal assessment for breast development was 77.2 and specificity was 94.3. In girls aged ≥11 years, self-assessment had higher sensitivity and specificity than maternal report. Specificity for both mothers and self, but not sensitivity, was significantly lower for overweight girls. In the overall cohort, maternal and daughter agreement for breast development and pubic hair development (T2+ vs T1) were similar (0.66, [95% confidence interval 0.58-0.75] and 0.69 [95% confidence interval 0.61-0.77], respectively), but declined with age. Mothers were more likely to report a lower Tanner stage for both breast and pubic hair compared with self-assessments. CONCLUSIONS: These differences in validity should be considered in studies measuring pubertal changes longitudinally when they do not have access to clinical assessments.

Original languageEnglish (US)
Article numbere20154571
JournalPediatrics
Volume138
Issue number1
DOIs
StatePublished - Jul 1 2016

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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Terry, M. B., Goldberg, M., Schechter, S., Houghton, L. C., White, M. L., O'Toole, K., Chung, W. K., Daly, M. B., Keegan, T. H., Andrulis, I. L., Bradbury, A. R., Schwartz, L., Knight, J. A., John, E. M., & Buys, S. S. (2016). Comparison of clinical, maternal, and self pubertal assessments: Implications for health studies. Pediatrics, 138(1), [e20154571]. https://doi.org/10.1542/peds.2015-4571