Comparison of classical and autogenous systems of regulation in inducible operons

Michael A. Savageau

Research output: Contribution to journal › Article

162 Citations (Scopus)

Abstract

The mechanism of autogenous regulation, whereby a protein directly controls the expression of its own structural gene, is compared on the basis of function with the classical mechanism, in which the structural gene of the regulator is itself unregulated. The autogenous mechanism is superior to the classical one in inducible catabolic systems governed by a repressor; the opposite is true if the regulator is an activator.

Original languageEnglish (US)
Pages (from-to)546-549
Number of pages4
JournalNature
Volume252
Issue number5484
DOIs
StatePublished - 1974
Externally publishedYes

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Regulator Genes
Operon
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

Comparison of classical and autogenous systems of regulation in inducible operons. / Savageau, Michael A.

In: Nature, Vol. 252, No. 5484, 1974, p. 546-549.

Research output: Contribution to journal › Article

Savageau, MA 1974, 'Comparison of classical and autogenous systems of regulation in inducible operons', Nature, vol. 252, no. 5484, pp. 546-549. https://doi.org/10.1038/252546a0
Savageau MA. Comparison of classical and autogenous systems of regulation in inducible operons. Nature. 1974;252(5484):546-549. https://doi.org/10.1038/252546a0
Savageau, Michael A. / Comparison of classical and autogenous systems of regulation in inducible operons. In: Nature. 1974 ; Vol. 252, No. 5484. pp. 546-549.
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