Comparison of classical and autogenous systems of regulation in inducible operons

Michael A. Savageau

doi:10.1038/252546a0

Comparison of classical and autogenous systems of regulation in inducible operons

Michael A. Savageau

Research output: Contribution to journal › Article › peer-review

168 Scopus citations

Abstract

The mechanism of autogenous regulation, whereby a protein directly controls the expression of its own structural gene, is compared on the basis of function with the classical mechanism, in which the structural gene of the regulator is itself unregulated. The autogenous mechanism is superior to the classical one in inducible catabolic systems governed by a repressor; the opposite is true if the regulator is an activator.

Original language	English (US)
Pages (from-to)	546-549
Number of pages	4
Journal	Nature
Volume	252
Issue number	5484
DOIs	https://doi.org/10.1038/252546a0
State	Published - 1974
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/252546a0

Fingerprint Dive into the research topics of 'Comparison of classical and autogenous systems of regulation in inducible operons'. Together they form a unique fingerprint.

Cite this

@article{d19e3f5f072d42ebbefecfc0b9b61cb4,

title = "Comparison of classical and autogenous systems of regulation in inducible operons",

abstract = "The mechanism of autogenous regulation, whereby a protein directly controls the expression of its own structural gene, is compared on the basis of function with the classical mechanism, in which the structural gene of the regulator is itself unregulated. The autogenous mechanism is superior to the classical one in inducible catabolic systems governed by a repressor; the opposite is true if the regulator is an activator.",

author = "Savageau, {Michael A.}",

year = "1974",

doi = "10.1038/252546a0",

language = "English (US)",

volume = "252",

pages = "546--549",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Publishing Group",

number = "5484",

}

TY - JOUR

T1 - Comparison of classical and autogenous systems of regulation in inducible operons

AU - Savageau, Michael A.

PY - 1974

Y1 - 1974

N2 - The mechanism of autogenous regulation, whereby a protein directly controls the expression of its own structural gene, is compared on the basis of function with the classical mechanism, in which the structural gene of the regulator is itself unregulated. The autogenous mechanism is superior to the classical one in inducible catabolic systems governed by a repressor; the opposite is true if the regulator is an activator.

AB - The mechanism of autogenous regulation, whereby a protein directly controls the expression of its own structural gene, is compared on the basis of function with the classical mechanism, in which the structural gene of the regulator is itself unregulated. The autogenous mechanism is superior to the classical one in inducible catabolic systems governed by a repressor; the opposite is true if the regulator is an activator.

UR - http://www.scopus.com/inward/record.url?scp=0016145568&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016145568&partnerID=8YFLogxK

U2 - 10.1038/252546a0

DO - 10.1038/252546a0

M3 - Article

C2 - 4431516

AN - SCOPUS:0016145568

VL - 252

SP - 546

EP - 549

JO - Nature

JF - Nature

SN - 0028-0836

IS - 5484

ER -

Comparison of classical and autogenous systems of regulation in inducible operons

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this