Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis

C. K. Walker, D. V. Landers, M. J. Ohm-Smith, M. O. Robbie, J. Luft, J. Schachter, Richard L Sweet

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Pelvic inflammatory disease (PID), one of the major sequelae of the current epidemic of sexually transmitted diseases, has been shown to be a polymicrobial infection. This study compares the efficacy and safety of two broad-spectrum combination drug regimens, cefotetan with doxycycline and cefoxitin with doxycycline, in the treatment of PID. A total of 108 patients with acute salpingitis were hospitalized and randomized into two treatment groups: cefotetan/doxycycline (N = 54) and cefoxitin/doxycycline (N = 54). Before antibiotic administration, Chlamydia trachomatis was identified in 17 (16%) of the patients, Neisseria gonorrhoeae from 72 (67%), and anaerobic and aerobic bacteria were identified from the endometrial cultures of 86 (80%). There were seven tubo-ovarian abscesses (TOAs) that were diagnosed in the cefotetan group, and six in the cefoxitin group. Clinical cure was achieved in 51 of 54 (94%) patients in each group. Of the six patients whose treatment failed, all had positive cultures for N. gonorrhoeae and facultative/anaerobic bacteria, whereas none had C. trachomatis. Two patients from each study arm whose treatment failed were diagnosed with TOAs and responded subsequently to clindamycin plus an aminoglycoside. Cultures that were obtained after the completion of inpatient treatment showed the eradication of C. trachomatis and N. gonorrhoeae in all patients. Also, both regimens were effective in reducing aerobic and anaerobic pathogens. Finally, both regimens were well tolerated, with few side-effects.

Original languageEnglish (US)
Pages (from-to)119-123
Number of pages5
JournalSexually Transmitted Diseases
Volume18
Issue number2
StatePublished - 1991

Fingerprint

Cefotetan
Salpingitis
Cefoxitin
Doxycycline
Inpatients
Neisseria gonorrhoeae
Chlamydia trachomatis
Pelvic Inflammatory Disease
Anaerobic Bacteria
Abscess
Therapeutics
Aerobic Bacteria
Clindamycin
Aminoglycosides
Drug Combinations
Sexually Transmitted Diseases
Coinfection
Anti-Bacterial Agents
Safety

ASJC Scopus subject areas

  • Dermatology
  • Microbiology (medical)
  • Public Health, Environmental and Occupational Health

Cite this

Walker, C. K., Landers, D. V., Ohm-Smith, M. J., Robbie, M. O., Luft, J., Schachter, J., & Sweet, R. L. (1991). Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis. Sexually Transmitted Diseases, 18(2), 119-123.

Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis. / Walker, C. K.; Landers, D. V.; Ohm-Smith, M. J.; Robbie, M. O.; Luft, J.; Schachter, J.; Sweet, Richard L.

In: Sexually Transmitted Diseases, Vol. 18, No. 2, 1991, p. 119-123.

Research output: Contribution to journalArticle

Walker, CK, Landers, DV, Ohm-Smith, MJ, Robbie, MO, Luft, J, Schachter, J & Sweet, RL 1991, 'Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis', Sexually Transmitted Diseases, vol. 18, no. 2, pp. 119-123.
Walker, C. K. ; Landers, D. V. ; Ohm-Smith, M. J. ; Robbie, M. O. ; Luft, J. ; Schachter, J. ; Sweet, Richard L. / Comparison of cefotetan plus doxycycline with cefoxitin plus doxycycline in the inpatient treatment of acute salpingitis. In: Sexually Transmitted Diseases. 1991 ; Vol. 18, No. 2. pp. 119-123.
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