Comparison of cardiac troponin I and lactate dehydrogenase isoenzymes for the late diagnosis of myocardial injury

Joseph T. Martins, Daj J. Li, Leland B. Baskin, Ishwarlal Jialal, Joseph H. Keffer

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Cardiac troponin I (cTnI) is a highly specific marker that is elevated in the blood for several days following myocardial infarction. The lactate dehydrogenase (LD) isoenzyme I to isoenzyme 2 ratio (LD1/LD2) is the established marker for the late diagnosis of myocardial infarction. In this study, the sensitivity of cardiac troponin I (cTnI) and LD1/LD2 were compared as late markers of myocardial injury over a 5-day period in 36 patients admitted with a diagnosis of myocardial infarction to the coronary care unit. Over this period, the sensitivity of cTnI was significantly greater than that of LD1/LD2 (P <.05). The concurrent elevation of both cardiac markers of the five day period range from 53.1% to 79.4%. However, this low concordance was largely due to an LD1/LD2 <1 in the presence of an increased cTnI. The average discordance over the 5-day period was 29.5%. Because cardiac troponin I (cTnI) has greater sensitivity than lactate dehydrogenase isoenzymes for delayed diagnosis of myocardial injury and is a more cost-effective test, the authors recommend it as a test of choice in this setting.

Original languageEnglish (US)
Pages (from-to)705-708
Number of pages4
JournalAmerican Journal of Clinical Pathology
Volume106
Issue number6
StatePublished - Dec 1996
Externally publishedYes

Keywords

  • LD isoenzymes
  • Myocardial injury
  • Troponin I

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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